Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.

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Recently Added/Updated trials

HOPE-EHK

18 years - 99 years

All genders

Target population: HIV+ kidney txp recipients who are willing to accept an organ from an HIV+ deceased donor. Purpose: to quantify the association, if any, b/t donor HIV status and risk of rejection in kidney txp recipients, determine long-term outcomes, and understand the immunologic and virologic mechanisms of rejection in HIV-infected recipients from a donor w/ or w/out HIV. Main study procedures: blood/tissue/data collection.

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M24-885

99 years or below

All genders

The purpose of this study is to evaluate the safety and efficacy of using multiple medicines compared to a single medicine in subjects with moderate to severe Crohn's Disease. Each group will have a 35-day screening period, followed by a 12-week induction period, a 12-week maintenance period, and a follow-up phone call. At the end of the Maintenance period the doctor may recommend that the subject participate in a long-term extension study.

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VRDN-003-302

99 years or below

All genders

To determine the efficacy of subcutaneously administered VRDN-003 using every 4-weeks (Q4W) or every 8-week (Q8W) regimen compared to placebo in participants with chronic TED. Non-responders may receive additional open-label treatment with VRDN-003.

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CART123 + Ruxolitinib in Relapsed/Refractory AML

99 years or below

All genders

See protocol section 2. See protocol section 2. See protocol section 2.

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TAMBE AAA 24-01

99 years or below

All genders

To confirm that the benefit-risk assessment of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis (TAMBE Device) remains positive in real-world use and to ensure the adequacy of the TAMBE Device training program.

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Currently seeking healthy volunteers for research studies.

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CureTalks@Penn interviews Penn Medicine physicians about their cutting edge research and clinical trials. Our goal is to inform patients, care-givers, patient advocates and other physicians about research that occurs at Penn Medicine.