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Found 35 cardiology trials
A listing of cardiology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This is a multicenter, randomized, quadruple-blind, sham controlled, 2-part, embedded IDE clinical trial. The main objective is to evaluate the efficacy and safety of Cardiac Contractility Modulation (CCM) therapy in patients with symptomatic HF with LVEF 40-60%. The study is divided into 3 phases, screening, randomization (where 2/3 will be …
To evaluate the efficacy of NTLA-2001, as measured by the composite risk of CV-related mortality and CV events (urgent HF visits and hospitalizations due to HF, MI, arrhythmia, or stroke), compared to placebo Composite endpoint comprising Cardiovascular related mortality and frequency and timing of Cardiovascular events (urgent Heart Failure visits …
This study investigates high-risk pulmonary embolism.The study evaluates the effectiveness and safety of an investigational device compared to standard care for individuals with this condition.Who can participate: Adults aged 18 and older with a specific type of pulmonary embolism can participate. Key factors include evidence of a clot in the …
The AG10-501 ACT-EARLY study is a randomized, multicenter, double-blind, placebo-controlled study of acoramidis for prevention of ATTR. The objective of this study is to evaluate if the use of acoramidis as a prophylactic intervention in individuals who are carriers of a known pathogenic TTR variant but with no clinical evidence …
This study investigates ATTR amyloidosis with cardiomyopathy. The purpose of this study is to evaluate the effects of an investigational medication compared to a placebo.This study evaluates the safety and effectiveness of the investigational medication on cardiovascular events and patient-reported health status.Who can participate: Adults with a diagnosis of ATTR …
This is a post-market, prospective, multi-center, two-arm randomized-controlled clinical study. Subjects will be randomized in a 1:1 ratio into two arms: a treatment arm (use of vMap system in addition to pulmonary vein isolation [vMap+PVI]) and a control arm (PVI alone).The study is designed to compare clinical outcomes following use …
This is an observational, prospective, multi-center, non-randomized, real-world registry designed to obtain clinical experience with the FARAPULSE Pulsed Field Ablation System for the treatment of atrial fibrillation (AF). All types of AF including paroxysmal, persistent and long standing persistent may be included. Patient assessments will occur at pre- procedure, procedure, …
This is a Phase III, multi-centre, randomised, double-blind, parallel-group, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death …
This is a global, multicenter, prospective, observational study designed to document clinical characteristics and treatment patterns of adult patients with ATTR-CM treated with vutrisiran or other approved ATTR-CM treatments and to evaluate long-term effectiveness of vutrisiran compared to other approved ATTR-CM treatments. Data will be collected retrospectively and prospectively from …
This is an interventional, randomised, multinational, multicentre, two arm parallel-group, double-blind study. The aim of this study is to evaluate the effect of NNC6019-0001 4800 mg versus placebo in participants with variant or wild-type transthyretin (TTR) amyloid cardiomyopathy (ATTRv-CM or ATTRwt-CM, respectively)
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