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Found 8 diabetes-and-metabolism trials

A listing of diabetes-and-metabolism medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized  open-label  cross-over trial
18 years - 50 years
All genders
The research study is being conducted to better understand Cystic-Fibrosis Related Diabetes (CFRD) and to see the effects of an analog of the gut incretin hormone, GLP-1 (dulaglutide), has on individuals like with abnormal glucose tolerance. GLP-1 (dulaglutide) helps the pancreas release insulin, which controls blood sugar levels from getting …
A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus with Impaired Hypoglycemic Awareness and Severe Hypoglycemia
18 years - 65 years
All genders
Phase 1/2
Interventional
In T1D the body’s immune system destroys insulin producing cells called beta cells. This meansthe body cannot produce enough insulin to control the amount of sugar in the blood. Beta cellsare located in the pancreas and are part of clusters of cells called pancreatic islets.These cells produce hormones such as …
TZIELD® (teplizumab-mzwv) in Patients with Stage 2 Type 1 Diabetes
8 years or above
All genders
Are you at risk for type 1 diabetes?Are you willing to receive a phone call every 6 months?For patients treated with TZIELD AND NOT treated with TZIELDYou may qualify to participate in an observational research studyAn observational study (you will not receive any experimental medication)Does not require on-site visitsParticipation will …
Closed Loop and Education for hypoglycemia Awareness Restoration (CLEAR)
18 years - 75 years
All genders
Do you have Type 1 Diabetes for more than 10 years? The purpose of this study is to learn how to improve hypoglycemia unawareness - a condition where people with T1D may not be able to tell how low their blood sugar levels are. Hypoglycemia unawareness happens because their body’s response …
Emergence and Progression of Abnormal Glucose Tolerance in Cystic Fibrosis (Aim 1)
6 years - 50 years
All genders
The purpose of this research study is to test how high blood sugar develops and worsens over time in some people with cystic fibrosis.If you agree to take part, your participation can last for up to 7 years.As a participant in this research, all participants will:Complete overnight fastingComplete Mixed Meal …
Cadisegliatin as Adjunctive Therapy in Type 1 Diabetes: A 26-Week Double-Blind, Randomized, Placebo-Controlled Phase 3 Study
18 years or above
All genders
Phase 3
The purpose of this study is to learn about and compare the effects of cadisegliatin (also called “TTP399”) compared to placebo to find out which is better for reducing the episodes of low blood sugar (hypoglycemia) related to type 1 diabetes, lowering HbA1c, and to see how safe cadisegliatin is …
INHALE-AIDEx: A Randomized Crossover Trial Evaluating the Effect of Inhaled Technosphere Insulin (Afrezza®) Versus Rapid Acting Analogue Insulin on Exercise-induced Hypoglycemia in Adults with Type 1 Diabetes Using Automated Insulin Delivery
18 years - 60 years
All genders
This study is being done to find out if inhaled insulin given for a meal is safer and better to use than a bolus of insulin through the pump when exercising following a meal.
18 years - 99 years
All genders
Phase 1
The primary objectives are to determine the pharmacokinetic (PK) and pharmacodynamic (PD) response of dorzagliatin 75 mg twice daily following 7-day administration in individuals with PI-CF and abnormal glucose tolerance (EGI, IGT or CFRD) when compared to 7-day administration of placebo according to a randomized, double-blind cross-over study design. The …