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Found 6 Down's Syndrome trials

A listing of Down's Syndrome medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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18 years or above
Female
The purpose of this study is to investigate if minimally invasive surgery, called robotic assisted laparoscopy (small incision surgery), is better or worse than open surgery (otherwise known as a laparotomy) when performing a radical hysterectomy for cervical cancer. A radical hysterectomy is surgery to remove the uterus, cervix, the …
55 years - 85 years
All genders
Phase 2
To assess the effect of donanemab versus placebo on cognitive and functional progression in participants with established alpha-synuclein and amyloid co-pathology
Cardiometabolic Effects of Dipeptidyl Peptidase IV and Related Pathways
18 years - 99 years
All genders
DPP4 is an enzyme that breaks down proteins that may affect blood sugar and the heart. We will recruit individuals from the Penn Biobank (cases, controls). Participants will be asked to complete a meal test, DXA, and echocardiogram with exercise. A cardiac MRI and related pilot study are optional.
18 years or above
All genders
Phase 1
Interventional
This study investigates the safety and effects of an investigational radioligand therapy in adults with advanced or metastatic solid tumors that have high levels of fibroblast activation protein (FAP). The study aims to understand how the investigational therapy interacts with FAP. The purpose of this study is to evaluate the …
18 years or above
All genders
Phase 2
Interventional
This study investigates the effectiveness of an investigational medication combined with ipilimumab in patients with metastatic pancreatic cancer. The purpose is to understand if this combination can slow tumor growth and what side effects may occur. Participants will be placed into two study arms: Arm A will receive the investigational …
18 years - 89 years
All genders
Interventional
This study investigates the best way to treat patients with Barrett's esophagus and low-grade dysplasia by comparing two procedures: endoscopic surveillance and endoscopic eradication therapy. Low-grade dysplasia is an early form of abnormal cell growth that may not always progress to cancer. Endoscopic surveillance involves using a camera-equipped tube to …