Clinical Research Opportunities

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.

Recently Added/Updated trials

RADIATE-VT VAR-2022-01

All genders
The principal hypothesis of the Varian CRA randomized trial is that Varian CRA is safer and provides at least equivalent efficacy compared to repeat CA for patients with high-risk refractory VT who have experienced VT recurrence after CA and are candidates for additional CA.

A Phase 2 study of JNJ-90301900 with chemoradiation and durvalumab for non-small cell lung cancer

18-99 years
All genders
A Phase 2, randomized, open-label, active-controlled study of JNJ-90301900 in combination with chemoradiation followed by durvalumab in locally advanced and unresectable Stage III non-small cell lung cancer.

Linerixibat Long-term Safety and Tolerability Study (LLSAT)

All genders
Long-term Safety and Tolerability Study of Linerixibat for the Treatment of Cholestatic Pruritus in Participants with Primary Biliary Cholangitis

LGH IRB 2024-32: ACCLAIM-Lp(a) EZEF

All genders
About 12,500 participants will be randomly assigned in a 1:1 ratio to receive either lepodisiran or placebo, added to their existing standard-of-care background medications. The first 3 doses are 6 months apart. All remaining doses are 12 months apart (Q12M) until the end of the study. In this event-driven study, the median study duration will be ~4 years until at least 1276 participants experience at least 1 event. The minimum study duration for each participant is expected to be 2 years.

LGH 2024-5: BOLT

All genders
The primary aim of mechanical aspiration thrombectomy using the Indigo Aspiration System is to safely achieve removal of clot burden to improve blood flow in the deep venous system. The purpose of this study is to evaluate the safety and efficacy of mechanical aspiration thrombectomy as a single session endovascular treatment approach, using the Indigo Aspiration System in patients with DVT.

Volunteer Sign-up

Participate in medical studies to develop new diagnostic and clinical treatments and improve current standards of care.

Healthy Volunteers

Currently seeking healthy volunteers for research studies.

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CureTalks@Penn interviews Penn Medicine physicians about their cutting edge research and clinical trials. Our goal is to inform patients, care-givers, patient advocates and other physicians about research that occurs at Penn Medicine.

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