Found 390 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates an investigational medication for people with advanced cancers that are positive for the PRAME protein. The study aims to understand the safety and effectiveness of this investigational medication in adults who have a specific genetic marker called HLA-A*02:01 and PRAME-positive tumors.Participants in this study will receive the …
This study investigates the safety, tolerability, and anti-tumor activity of an investigational medication in adult patients with solid tumors that express MAGE-A4, a specific tumor-associated antigen. The study focuses on individuals with the HLA-A*02:01 tissue marker, which is necessary for participation.Participants will undergo various study procedures to evaluate the maximum …
To develop PDX models or tumor cell lines of tumors from subjects with lymphoproliferative disorders enrolled to L-RAD (IRB #832203).
This study investigates whether primary palliative care can serve as an alternative to specialty palliative care in improving the quality of life, symptoms, mood, coping, and end-of-life outcomes for patients with acute myeloid leukemia (AML). These patients face a sudden, life-threatening diagnosis requiring immediate hospitalization and treatment, which can cause …
To explore secondary malignancies in subjects enrolled to the L-RAD study (IRB #832203, Lymphoproliferative Disorders: Biological Specimen Repository and Clinical Database) who received CAR T-cells or other T-cell directed therapies for lymphoproliferative disorders and to investigate potential relationships between prior T-cell directed therapy for lymphoma and subsequent malignancies.
This study investigates an investigational medication for patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors that have a specific change in the anaplastic lymphoma kinase (ALK) gene. The purpose of this study is to find out how safe and tolerable the investigational medication is, and to …
PURPOSE We would like to accrue patients consecutively over a several year period in order to collect tissue from many histopathologic subsets of nervous system tumors. Primary brain tumors occur nationally at a rate of approximately 17,000 new cases annually and within this group there are numerous subtypes. At the …
This study investigates an investigational medication for people with advanced or metastatic malignant mesothelioma or other solid tumors. The purpose of this study is to evaluate the safety, tolerability, and early effectiveness of the investigational medication. The study is conducted in two parts: a dose escalation part to determine the …
This study investigates the effectiveness and safety of an investigational medication activated by radiotherapy, with or without cetuximab, for elderly patients who cannot receive platinum-based chemotherapy. The focus is on individuals with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Participants are divided into two study arms to compare …
This study investigates the effectiveness of a combination of three investigational medications in treating advanced non-small cell lung cancer (NSCLC). The purpose of this study is to see if these medications can shrink tumors or slow their growth in participants who have previously received chemotherapy and immunotherapy.Participants in this study …
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