Found 141 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
This clinical trial studies how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. …
A Phase 2 study to evaluate the clinical activity, safety, and potentially predictive biomarker profile of ZN-c3 in subjects with High-Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
PURPOSE The overall objective is to demonstrate that the addition of ianalumab (either 3mg/kg or 9mg/kg dosage) to standard care (eltrombopag) is more effective and safer compared to the standard of care (eltrombopag) alone. Primary outcome variable is determined by the time to treatment failure which is in turn determined …
PURPOSE To evaluate the efficacy of ianalumab (i.e., platelet response 50 G/L) in participants with primary ITP previously treated with at least a corticosteroid and a TPO-RA. A platelet count of 50 G/L at two (or more) consecutive assessments at least 7 days apart between Week 1 Day 1 and …
To demonstrate that the addition of ianalumab to standard first-line corticosteroids prolongs Time to Treatment Failure compared to Corticosteroids alone in participants with primary ITP. ITP means immune thrombocytopenia. Time from randomization to treatment failure which is defined as Platelet count below 30G/L after 8 weeks from randomization. Need for …
To determine if overall survival (OS) is improved with proton beam therapy (PBT) treatment as compared to intensity modulated radiation therapy (IMRT) as part of planned protocol treatment for patients with esophageal cancer. To determine if OS with PBT is non-inferior to IMRT as part of planned protocol treatment and …
To evaluate the effects of VLX-1005 compared to placebo on platelet count recovery, an important clinical outcome in patients with positive serotonin release assay (SRA+) confirmed HIT, on a background of standard of care (SoC) anticoagulation -To evaluate the effects of VLX-1005 compared to placebo on platelet count recovery, an …
To evaluate the efficacy of SPK-8011 in preventing bleed episodes compared with FVIII prophylaxis in patients with hemophilia A without FVIII inhibitors on routine FVIII prophylaxis. To evaluate the efficacy of SPK-8011 in preventing bleed episodes compared with FVIII prophylaxis in patients with hemophilia A without FVIII inhibitors on routine …
Please refer to Protocol Section 2.1 (Objectives). Please refer to Protocol Section 2.2.1 (Primary Endpoints). Please refer to Protocol Section 2.2.2 (Secondary Endpoints).
The primary objective of the present study is to evaluate the efficacy (effectiveness) of prophylactic (preventative doses) of emicizumab (FDA approved, also called Hemlibra) administered on a regular scheduled basis to prevent bleeds in patients with acquired hemophilia A (AHA). The secondary objectives are to study the safety of emicizumab …
