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Found 116 surgery trials

A listing of surgery medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 NRG-CC008: A study to compare two surgical procedures in women with BRCA1 mutations to assess reduced risk of ovarian cancer
50 years and younger
Female
This clinical trial studies how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. …
 Treatment In Thoracic Aortic Aneurysm: Surgery versus Surveillance
18-79 years
All genders
This study aims to compare the outcomes of patients undergoing early surgical intervention for ascending aortic aneurysms to those undergoing aneurysm surveillance. Patients with aneurysm diameters between 5.0 and 5.4 cm will be randomized to receive either medical therapy or elective surgery and will be followed annually for 5 years. …
99 years and younger
All genders
The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC) which includes either pembrolizumab or pembrolizumab plus capecitabine in participants with triple negative breast cancer …
 A Randomized, Open-Label, Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy
18-100 years
Female
Phase 3
The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC) which includes either pembrolizumab or pembrolizumab plus capecitabine in participants with triple negative breast cancer …
99 years and younger
All genders
The primary objective of this study is to assess whether preoperative hemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of patients with high risk de-differentiated liposarcoma DDLPS) and leiomyosarcoma (LMS) as measured by disease-free survival.
 Improving Clinical Outcomes of Auditory Brainstem Implantation with Speech-Evoked Auditory Brainstem Responses
18-99 years
All genders
The goal of this study is to improve the reliability of acquiring open-set speech recognition following ABI placement for retrocochlear deafness, to evaluate whether state of consciousness influences speech-based ABR. The researchers hypothesize that: 1) It will be possible to elicit speech-based ABR from surgically anesthetized patients. 2) Surgically anesthetized …
18-99 years
All genders
Interventional
The purpose of this trial is to determine whether Phasix™ Mesh helps prevent incisional hernias that sometimes occur after abdominal surgery by strengthening the closure of the tissue and/or the incision following surgery.
 Testing novel drugs or drug combinations to treat breast cancer before surgery
18-99 years
Female
A clinical trial to determine whether adding experimental agents to standard neoadjuvant paclitaxel (with or without trastuzumab), anthracycline, nad cyclosphosphamide increases the probability of pathologic complete response (pCR) over standard neoadjuvant chemotherapy for each biomarker signature established at trial entry, and to determine for each experimental agent used, the predictive …
18-50 years
All genders
Interventional
COSMID is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. The goal of the COSMID trial is to answer the question: For patients with QoL-limiting diverticular disease, is elective colectomy more effective than best medical …
 Surgical Therapy for Obstructive Sleep Apnea on Blood Pressure & Peripheral Arterial Tonometry
18-90 years
All genders
The research study is being done to look at the effect of sleep apnea surgery on different measures ofcardiovascular (heart) function in people with obstructive sleep apnea.
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