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Found 129 surgery trials

A listing of surgery medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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18 years or above
All genders
Phase 2
Interventional
This study investigates the effects of a combination of investigational medication and PD-1 inhibition on recurrent IDH-mutant glioma, a type of brain tumor. The purpose of this study is to see if this combination can stimulate an immune response against the tumor.Participants in this study will undergo different procedures depending …
UPCC 04221 Collection of Samples from the United States Population for Optimization and Evaluation of Colorectal Cancer (CRC) Plasma Circulating Free-DNA (cfDNA) Marker Panel Performance (USOPTIVAL)
45 years - 84 years
Accepts healthy volunteer
All genders
This study investigates the use of circulating free-DNA (cfDNA) markers in blood to improve detection of colorectal cancer (CRC) and advanced adenomas. The purpose of this study is to collect blood samples and clinical data from participants in order to optimize a biomarker panel for better detection of these conditions.Participants …
UPenn Stent-Graft Study
18 years - 99 years
All genders
This study will assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aortic aneurysms and aortic arch aneurysms or TAAA) in patients at high risk for open surgery in two study arms. Participants that choose to sign the informed consent and …
35 years - 50 years
Female
Interventional
This study investigates the effectiveness of two surgical procedures in reducing the risk of ovarian cancer in individuals with BRCA1 mutations. The purpose of this study is to compare bilateral salpingectomy, which involves removing the fallopian tubes, with bilateral salpingo-oophorectomy, which involves removing both the fallopian tubes and ovaries. These …
50 years - 75 years
All genders
Observational
This study investigates different methods for monitoring pancreatic cysts. Monitoring these cysts is important to prevent complications. The purpose of this study is to compare two approaches: more frequent monitoring versus less frequent monitoring, to see which one leads to better outcomes for patients with pancreatic cysts.Participants in the study …
All genders
Phase 3
Interventional
This study investigates the effectiveness of active surveillance and chemotherapy in treating germ cell tumors. The purpose of this study is to see if monitoring patients who have low-risk tumors after surgery can help maintain high survival rates without immediate further treatment. The study also aims to determine whether carboplatin …
UPCC 21920 Randomized Trial of Universal vs. Guideline-Directed Germline Testing Among Young Adults with Cancer
18 years - 40 years
All genders
Interventional
The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. …
18 years - 40 years
All genders
Interventional
This study investigates the genetic risk in young adults with cancer and their relatives. The purpose is to understand how universal genetic testing can identify individuals with a higher risk of cancer who might be missed by traditional testing methods. This study involves young adult cancer patients, aged 18 to …
18 years or above
Female
Phase 2
Interventional
The purpose of this study is to assess the safety and effectiveness of a combination of investigational medication and another drug in treating advanced-stage ovarian, fallopian tube, or primary peritoneal cancer. This study targets cancers that express a specific protein called folate receptor alpha (FRα). This protein is found on …
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