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Found 79 Chemotherapy trials
A listing of Chemotherapy medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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Single patient compassionate use protocol. Received palliative first-line treatment with FOLFIRINOX/FOLFIRI from 6/2017 through 4/2018 at which time her disease remained stable. The patient was suffering from cumulative chemotherapy toxicities and therefore elected to enroll in UPCC 35217, a trial of maintenance niraparib with either nivolumab or ipilimumab in patients …
Phase 2: To evaluate BICR-assessed objective response rate at each dose level of R-DXd. Phase 3:To evaluate BICR-assessed objective response rate with R-DXd treatment compared with investigator's choice of paclitaxel, PLD, gemcitabine, or topotecan. Objectives, outcome measures, and endpoints are located in Tables 3.1 and 3.2 of the protocol. Phase …
The purpose of this study is to investigate the effectiveness and safety of an investigational medication compared to standard endocrine therapy for patients with ER+/HER2- early breast cancer. The study focuses on patients who have completed locoregional treatment, which may include surgery and radiotherapy, and are at intermediate-high or high …
This study investigates the use of previously cryopreserved ovarian tissue to restore fertility in women who have experienced infertility or ovarian insufficiency after cancer treatments. The purpose of this study is to determine the safety and effectiveness of transplanting this tissue back into the patient's body.Participants in this study will …
This study investigates metastatic castration-resistant prostate cancer (mCRPC). The purpose of this study is to compare the effectiveness of an investigational medication, ifinatamab deruxtecan, against standard chemotherapy in extending the lives of participants and delaying cancer progression.Participants in the study will receive either the investigational medication or chemotherapy. The study …
This study investigates head and neck squamous cell carcinoma. The purpose of this study is to evaluate the safety and effectiveness of an investigational medication when used with standard chemotherapy and radiation therapy.The study focuses on assessing how well the investigational medication works with chemoradiation therapy. It evaluates the treatment's …
This study investigates the use of CART123 cells in combination with ruxolitinib for patients with relapsed or refractory acute myeloid leukemia (AML). The purpose of this study is to assess the safety and early effectiveness of this combination treatment. Participants will receive a single infusion of CART123 cells after being …
This study investigates the use of investigational medications for treating advanced or metastatic non-small cell lung cancer (NSCLC) with a specific genetic mutation known as KRAS G12C. The purpose of this study is to compare the effects of calderasib, a targeted therapy, combined with subcutaneous pembrolizumab, against a combination of …
This study investigates the use of investigational medications following CAR T-cell therapy for individuals with relapsed or refractory large B-cell lymphoma and grade IIIB follicular lymphoma. The purpose of this study is to determine if additional treatment with investigational medications, after initial chemotherapy and CAR T-cell therapy, can better manage …
This is an investigator-initiated, open label phase Ib study examining 2nd line atezolizumab and tocilizumab in a cohort of recurrent/metastatic non-small cell lung cancer patients who have received prior immune checkpoint inhibitor therapy with or without other forms of therapy (i.e. chemotherapy, radiation). Patients with driver mutations in EGFR, ALK, …
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