Found 79 Chemotherapy trials
A listing of Chemotherapy medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the effectiveness of preoperative chemotherapy followed by surgery compared to surgery alone in patients with high-risk retroperitoneal sarcoma, specifically dedifferentiated liposarcoma (DDLPS) and leiomyosarcoma (LMS). The study aims to determine if adding chemotherapy before surgery can improve disease-free survival for these patients.Participants in the study will be …
This study investigates the efficacy and safety of an investigational medication in combination with chemotherapy for treating individuals with metastatic HER2-positive breast cancer. Participants in this study have previously been treated with a specific medication called T-DXd but have either not responded or cannot tolerate it.Participants will be randomly assigned …
This study investigates the use of investigational cells called CART-EGFR-IL13Ra2 in patients with recurrent glioblastoma, a type of brain cancer. The study aims to evaluate the safety and effectiveness of these cells in patients whose cancer has returned after previous treatment.Participants will receive CART-EGFR-IL13Ra2 cells along with chemotherapy or before …
This study compares the impact of using a combination of drugs, ramucirumab and pembrolizumab, versus standard chemotherapy for treating advanced non-small cell lung cancer that is stage IV or recurrent. Ramucirumab blocks new blood vessel growth that tumors need, while pembrolizumab boosts the immune system to fight cancer. The trial …
This study investigates treatments for adults newly diagnosed with BCR-ABL-positive Acute Lymphoblastic Leukemia (ALL). The purpose of this study is to compare the effectiveness of a standard treatment involving chemotherapy, steroids, and a type of medicine called a tyrosine kinase inhibitor (TKI) with a treatment that adds another medicine called …
This study investigates treatments for non-small cell lung cancer (NSCLC). The purpose of this study is to evaluate the effectiveness of investigational agents, alone or in combination with pembrolizumab and chemotherapy, in treating NSCLC. Pembrolizumab is a type of immunotherapy that helps the immune system fight cancer cells. The study …
This study investigates the use of investigational medications in combination with pembrolizumab, with or without chemotherapy, for people with Stage IV non-small cell lung cancer (NSCLC). The purpose of this study is to evaluate the safety and effectiveness of these treatment combinations in participants who have not previously received treatment …
This study investigates the effects of an investigational medication, ORIC-114, on patients with advanced solid tumors that show changes in certain genes known as EGFR or HER2. The purpose of this study is to determine the best dose for Phase 2 trials and to evaluate the safety and effectiveness of …
This study investigates the effectiveness and safety of using Tumor Treating Fields (TTFields) in combination with pembrolizumab and platinum-based chemotherapy for treating metastatic non-small cell lung cancer (NSCLC). The purpose of this study is to assess how well patients survive overall and how long they live without the disease getting …
This study investigates the safety and effectiveness of adding RP2, an investigational treatment, to the standard chemotherapy regimen, FLOT, for patients with stage II or higher, non-metastatic gastroesophageal adenocarcinoma. The purpose of this study is to determine if injecting RP2 directly into the tumors of the stomach and esophagus, combined …
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