Found 76 Lung Disease trials
A listing of Lung Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the effect of adding radiation therapy to the usual maintenance therapy with an investigational medication in patients with extensive stage small cell lung cancer. This study aims to compare the progression-free survival and overall survival of patients receiving the investigational medication alone versus those receiving it with …
This study investigates the safety and effectiveness of an investigational antibody-drug conjugate in combination with an immune checkpoint inhibitor, with or without carboplatin, for individuals with extensive stage small cell lung cancer (ES-SCLC). The purpose of this study is to explore how these treatments work together in the first-line setting, …
This study investigates the effectiveness of a combination of three investigational medications in treating advanced non-small cell lung cancer (NSCLC). The purpose of this study is to see if these medications can shrink tumors or slow their growth in participants who have previously received chemotherapy and immunotherapy.Participants in this study …
This study investigates treatment options for non-small cell lung cancer (NSCLC), focusing on patients who undergo surgery. The purpose is to determine if adding an investigational medication to pembrolizumab post-surgery is more effective in preventing disease recurrence in patients who did not achieve a pathological complete response (pCR) after initial …
A single-dose, open-label, dose-escalation Phase 1b study in patients scheduled to undergo minimally invasive surgery (MIS) for known or suspected lung cancer via thoracoscopy (i.e., VATS). Single dose IV administration of Pemofolacianine for Injection, either on the day before surgery or on the day of surgery, with 2 different doses …
Among lung transplant recipients who survive to 5 years, half suffer from chronic lung allograft dysfunction (CLAD). This study will evaluate how changes in the lung microbiome may cause CLAD in Cystic Fibrosis patients who have been transplanted. This is a case-control study of Cystic Fibrosis lung transplant recipients to …
This study compares the impact of using a combination of drugs, ramucirumab and pembrolizumab, versus standard chemotherapy for treating advanced non-small cell lung cancer that is stage IV or recurrent. Ramucirumab blocks new blood vessel growth that tumors need, while pembrolizumab boosts the immune system to fight cancer. The trial …
The purpose of this study is to investigate the effectiveness of an investigational medication in patients with HER2-positive solid tumors that are locally advanced, unresectable, or metastatic. In this study, HER2-positive is identified as IHC 3+. The study focuses on patients who have previously received systemic treatment for their condition …
This study's primary objective will be to create a database of lung cancer patients treated with immunotherapy agents and to access Remnant (left-over) tissue collected from clinically-indicated procedures/surgery for analyses, to determine factors that predict response to immunotherapy, and/or the toxicity prole of patients treated with immunotherapy.
This study investigates non-squamous non-small cell lung cancer. It focuses on patients with advanced or metastatic forms of this condition who have previously been treated and do not have actionable genomic alterations.The study evaluates the effectiveness and tolerability of an investigational medication compared to standard care. It also involves an …
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