Clinical Research Opportunities

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.

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Recently Added/Updated trials

 Dynamic Nuclear Polarization-MR Spectroscopic Imaging of Hepatocellular Carcinoma Metabolism to Predict Response Following Locoregional or Systemic Therapy

Dynamic Nuclear Polarization-MR Spectroscopic Imaging of Hepatocellular Carcinoma Metabolism to Predict Response Following Locoregional or Systemic Therapy

18-99 years
All genders
Phase 2
Interventional
The research study is being conducted to evaluate a new imaging technique for detecting the response of hepatocellular carcinoma (HCC) to locoregional or systemic therapy. Locoregional therapies or LRT are called Transarterial Chemoembolization or TACE, Transarterial Radioembolization or TARE and Microwave Ablation or MWA. Systemic therapies or ST are therapy drugs that spread throughout the body to treat cancer cells. They include chemotherapy, hormonal therapy, targeted drugs, and immunotherapy.
 Effects of the Contraceptive Implant in Women with Sickle Cell Disease (SCD CURE)

Effects of the Contraceptive Implant in Women with Sickle Cell Disease (SCD CURE)

18-45 years
Female
This research is being done to see if women who have sickle cell disease (SCD) experience any difference in their pain while using a hormonal implant as compared to when not using a hormonal implant (Nexplanon). We are seeking women between the ages of 18 and 45 who have been diagnosed with SCD and have had at least 3 vaso-occlusive pain episodes in the previous 6 months. If you agree to join the study, you will be asked to complete the following research procedures: you will complete a 3-month “baseline” with no use of hormonal contraception (such as the birth control pill, ring, or injection), and then will have a contraceptive implant (Nexplanon) placed for 6 months. Your participation will last for a total of 9 months, with 3 in-person visits with a urine pregnancy test, blood draw, and surveys, as well as the completion of a daily text message questionnaire.

MVT-601A-006 MOXIE

All genders
The primary objective of this study is to characterize changes in bone mineral density (BMD) during continuous treatment with relugolix combination tablet (relugolix 40 mg/estradiol [E2] 1 mg/norethindrone acetate [NETA] 0.5 mg) for up to 48 months (4 years) in two cohorts: (1) premenopausal women with heavy menstrual bleeding associated with uterine leiomyomas (fibroids) and (2) premenopausal women with moderate to severe pain associated with endometriosis.

HPTN 102/PURPOSE 3

Female
Phase 2
This is a Phase 2, open-label, multicenter, randomized study to evaluate the PK, safety, and acceptability of LEN subcutaneous (SC) injection compared with oral F/TDF in cisgender women who would benefit from PrEP. This study has 2 parts. Randomized Phase: ppts will be randomized in a 1:1 ratio to receive 52 wks of LEN or F/TDF, followed by up to 78 wks of F/TDF for both study drug groups in the PK Tail Phase. Participants in the LEN group will transition to F/TDF for the PK Tail Phase.

Platform Trial

All genders
The phase 2/3 HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products (IP) for the treatment of ALS. IPs are tested in trial regimens (Regimen-Specific Appendix (RSA)). Patients will be randomized twice, first to one of the regimens, and second to the regimen study drug or placebo. Subjects will complete questionnaires, physical exams, motor tests and biological samples collection.

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Participate in medical studies to develop new diagnostic and clinical treatments and improve current standards of care.

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Currently seeking healthy volunteers for research studies.

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CureTalks@Penn interviews Penn Medicine physicians about their cutting edge research and clinical trials. Our goal is to inform patients, care-givers, patient advocates and other physicians about research that occurs at Penn Medicine.

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