Clinical Research
Opportunities

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Get Started

Clinical Research Opportunities

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Get started

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Get started

Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.

Search by keywords

Please select a valid location from the dropdown

Browse by Condition or Investigator

Browse all Trials

Featured
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
All

Featured
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
All

Featured
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
All

Featured studies

UPCC 31920 Penn Medicine BioBank

The Penn Medicine Biobank is collecting and storing biological specimens such as blood, as well as health information from volunteers. These samples and this information allow researchers to use them for research studies including but not limited to COVID-19, cancer, diabetes, and heart disease.

View Details

The GRoceries Aimed at Increasing Nutrition Study (GRAIN Study)

We are looking for adults ages 45-70 to take part in an 18-week study about people‘s online grocery shopping habits. You’ll get a free Walmart+ membership for your grocery deliveries and receive $10 back on all weekly orders over $35. You may earn over $200 in total for completing study …

View Details

Adult Virome Study

Did you know that all of us, including all healthy people, have viruses in our bodies that do not make us sick but actually may contribute to health? Researchers are exploring the viruses that exist in people that are not currently sick in order to understand their role in human …

View Details

Click & Pick Study

The University of Pennsylvania is conducting a 6-week research study to learn about your experience using online grocery stores and online restaurant ordering applications.

View Details

MethaLoad Dose-Finding Study

Do you use fentanyl and want to start methadone? You may qualify for a paid research study at Penn Medicine. Methadone is usually started at a low dose that goes up slowly over days to weeks. Some people stay in withdrawal while their dose catches up. This study is testing …

View Details

Recently Added/Updated trials

Frexera

18 years - 70 years

All genders

Phase 2/3

The purpose of this research is to evaluate the tolerability of frexalimab (an investigational study drug) and its potential effectiveness to prevent graft rejection and preserve renal function over time, with potentially a reduced number of complications compared to standard of care.

Learn More

SPL-84

99 years or below

All genders

A phase 2a study with a specific mutation to evaluate SPL84.

Learn More

UPCC 03922 A Phase 1/1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 193 Alone and in Combination With Docetaxel in Subjects With Advanced MTAP-null Solid Tumors

18 years - 100 years

All genders

Phase 1/2

Interventional

The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of Anvumetostat alone and in combination with docetaxel in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-null solid tumors. The primary objective of Part 3 of this study is to evaluate the efficacy of Anvumetostat in adult participants with metastatic or locally advanced MTAP-null solid tumors.

Learn More

UPCC 51423 A First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-88549968, a T-cell Redirecting Bispecific Antibody for CALR-mutated Myeloproliferative Neoplasms

18 years or above

All genders

Phase 1

Interventional

The purpose of this study is to characterize safety and to determine the Recommended Phase 2 Dose (RP2D[s]) and optimal dosing schedule(s) of JNJ-88549968 in part 1 (Dose Escalation); to characterize the safety of JNJ- 88549968 at RP2D(s) in part 2 (Cohort Expansion). For U.S. sites: the purpose of this study is to characterize the safety and to determine the RP2D(s) and optimal dosing schedule(s) of JNJ-88549968 in Part 1 and part 1b (Dose Escalation), and to characterize the safety of JNJ-88549968 at the RP2D(s) in Part 2 and part 2b (Cohort Expansion), when given as monotherapy in essential thrombocythemia (ET) or myelofibrosis (MF), and with ruxolitinib or momelotinib in MF only.

Learn More

UPCC 04824 A Phase 3, Randomized Study of Adjuvant Cretostimogene Grenadenorepvec versus Observation for the Treatment of Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR-NMIBC) Following Transurethral Resection of Bladder Tumor (TURBT)

18 years or above

All genders

Phase 3

Interventional

This is a Phase 3, open-label, randomized trial designed to evaluate the RFS of TURBT followed by cretostimogene grenadenorepvec versus TURBT followed by surveillance for the treatment of participants with IR-NMIBC.

Learn More

Volunteer Sign-Up

If you don’t see a trial that fits your needs, consider joining our research volunteer registry. By signing up, you’ll be notified if a study matches your background and health profile.

Healthy Volunteers

Clinical research studies currently seeking healthy individuals.

View Studies

Virtual Studies

Also called Online or Decentralized studies. Some may be a mix of remote and in-person visits.

View Studies

Penn Medicine Logo Small

Penn Medicine experts answer questions from patient advocates and share groundbreaking medical developments happening at the University of Pennsylvania.