Clinical Research
Opportunities
Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate
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Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.
Featured studies
UPCC 31920 Penn Medicine BioBank
The Penn Medicine Biobank is collecting and storing biological specimens such as blood, as well as health information from volunteers. These samples and this information allow researchers to use them for research studies including but not limited to COVID-19, cancer, diabetes, and heart disease.
The GRoceries Aimed at Increasing Nutrition Study (GRAIN Study)
We are looking for adults ages 45-70 to take part in an 18-week study about people‘s online grocery shopping habits. You’ll get a free Walmart+ membership for your grocery deliveries and receive $10 back on all weekly orders over $35. You may earn over $200 in total for completing study …
Adult Virome Study
Did you know that all of us, including all healthy people, have viruses in our bodies that do not make us sick but actually may contribute to health? Researchers are exploring the viruses that exist in people that are not currently sick in order to understand their role in human …
Click & Pick Study
The University of Pennsylvania is conducting a 6-week research study to learn about your experience using online grocery stores and online restaurant ordering applications.
MethaLoad Dose-Finding Study
You may qualify for a paid research study that tests a new way of starting methadone for people using fentanyl. The standard approach to starting methadone uses low doses that increase slowly over time. This study tests whether a higher starting dose, called a loading dose, works better by reducing …
Recently Added/Updated trials
HMBeacon
The research study is being conducted to test the safety of ALN-6400 and find out what effects, if any, ALN-6400 has on people with Von Willebrand Disease (VWD) and Heavy Menstrual Bleeding (HMB).
GUARD
To evaluate the safety and effectiveness of the Surpass Elite with GUARDian Flow Diverter System (FDS) in the treatment of unruptured, wide-neck saccular or fusiform, intracranial aneurysms (IAs) located on the internal carotid artery (ICA) or its branches.
Taste & Saliva Study
Monell Chemical Senses Center in collaboration with Penn Medicine is conducting a study to understand how people perceive the quality and intensity of different tastes. To take part in this study, you must be healthy, between 18 and 45 years old, fluent in English, and willing to fast for at least one hour prior to each testing session.
TBCRC Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies (EVOLVE-BDT)
This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/hormone receptor-negative (ER+/HR-) and triple-negative (TN) metastatic breast cancer (MBC). The trial integrates both retrospective and prospective data collection, including archival tumor tissue, medical record abstraction, and prospective tumor and blood sampling prior to initiation of protocol directed treatment. Based on biomarker subtype, participants will receive standard of care therapy. Liquid biopsy will be collected on Cycle 2 Day 1, and then liquid biopsy, imaging and clinical data will be collected at each re-staging. Treatment will continue until discontinuation for progression, toxicity or at the discretion of the treating physician.
Healthy Volunteer Enteral Nutrition
This is an Outpatient clinical trial of 20 healthy people assigned to drink nutritional shakes for either 60% of their calories or 100% of their calories for up to 4 days to understand changes in microbiome and metabolome resulting from consumption of the assigned diet. Participants assigned to drink the nutritional formula for 60% of their calories will be given food for the other 40% of their calories. The assignment related to whether you will drink nutritional shakes and food vs. just nutritional shakes is random. You will not be able to choose your assignment. Participants may only drink the nutritional formula and the food provided along with water or black coffee for the 4 days of the study. You will need to come for 5 visits. One visit is for screening to see if you are eligible. The four other visits will take place in one week and will be in the morning, as fasting before the visit is required. Blood is collected at screening and on 3 other days. Stool and urine are collected at home around the time of screening and on 5 additional days. Participants are given sitz markers on day 1 and will undergo 1 or 2 x-rays. Diet surveys will also be collected. Participants who complete the entire study will receive $750.
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