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Found 50 Birth Defects trials

A listing of Birth Defects medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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18 years or above
All genders
Phase 2
Interventional
This study investigates the effects of adding investigational medications to the usual chemotherapy regimen for patients with peripheral T-cell lymphoma. The purpose of this study is to compare the effectiveness of three different treatment arms: one with the investigational medication duvelisib, another with the investigational medication CC-486, and the third …
UPCC 09321 Whole-Brain Spectroscopy Guided Personalized Mapping Of Transducer Arrays For Glioblastoma Patients Receiving Tumor Treating Fields
22 years or above
All genders
Interventional
This study investigates the effectiveness of personalized mapping techniques for patients with Glioblastoma, a type of brain cancer. The purpose of this study is to compare two different mapping methods used in tumor treating fields (TTFields) therapy, which is a type of electrical therapy that has shown to improve survival …
UPCC 20319 GBM AGILE: Global Adaptive Trial Master Protocol: An International, Seamless Phase II/III Response Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens In Newly Diagnosed and Recurrent GBM
18 years or above
All genders
Phase 2/3
Interventional
This study investigates therapies for glioblastoma, a type of brain cancer. The purpose of this study is to evaluate multiple therapies for newly diagnosed and recurrent glioblastoma using a response adaptive randomization platform. This method assigns participants to different study arms based on their performance, aiming to identify effective treatments …
18 years or above
All genders
Phase 1
Interventional
This study investigates the safety and feasibility of a treatment involving specialized T cells, known as CART-EGFR-IL13Ra2 cells, for patients with recurrent glioblastoma. The study focuses on patients whose tumors have a specific genetic feature called EGFR amplification.Participants in this study will receive an infusion of their own T cells …
18 years or above
All genders
Phase 1
Interventional
This study investigates the safety of using a type of immune cell therapy in patients with glioblastoma. The study will use T cells, which are a type of white blood cell, that have been modified to target specific proteins on cancer cells. These proteins are known as EGFR and IL13Ra2. …
18 years or above
All genders
Phase 2
Interventional
This study investigates the safety and effects of an investigational medication in adults with carcinoid syndrome. The purpose of this study is to evaluate how the investigational medication works in the body and its safety for people with this syndrome.Participants will first be randomly assigned to receive either the investigational …
18 years or above
All genders
Phase 1/2
Interventional
This study investigates the use of an investigational medication, a monoclonal antibody targeting Tumor Necrosis Factor Receptor 2 (TNFR2), in people with advanced malignancies. The purpose of the study is to evaluate the safety and tolerability of the investigational medication both alone and in combination with pembrolizumab, a type of …
18 years or above
All genders
Phase 1
Interventional
This study investigates the use of an investigational medication in comparison to primary surgery for individuals with early stage Cutaneous Squamous Cell Carcinoma (CSCC). This study aims to understand how the investigational medication affects the tumor and the body, as well as the potential side effects that may occur.Participants in …
UPCC 02110 I-SPY 2 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And Molecular Analysis 2)
18 years or above
All genders
Phase 2
Interventional
This study investigates personalized medicine approaches to determine which investigational medications are most effective for different types of breast cancer tumors. The purpose is to identify early indicators of treatment response, such as tumor analysis before surgery using MRI images, tissue, and blood samples, to predict treatment success.Participants will undergo …
18 years or above
All genders
Phase 3
Interventional
This study investigates the effectiveness of two different radiation therapy approaches, fractionated stereotactic radiosurgery (FSRS) and single fraction stereotactic radiosurgery (SRS), in treating patients with cancer that has spread to the brain. SRS involves delivering a single large dose of radiation to the tumor, while FSRS spreads the dose over …
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