Found 50 Birth Defects trials
A listing of Birth Defects medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the use of unlicensed cryopreserved cord blood units (CBUs) for transplantation in pediatric and adult patients with hematologic malignancies and other conditions. The purpose of this study is to understand how well patients recover neutrophil levels, a type of white blood cell important for fighting infections, after …
This study investigates the safety, tolerability, and pharmacokinetics of an investigational medication in participants with myeloproliferative neoplasms. This study is for those who have been previously treated with a JAK inhibitor and have specific types of myeloproliferative neoplasms, such as primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis.Participants in …
This study investigates the effectiveness and safety of an investigational medication activated by radiotherapy, with or without cetuximab, for elderly patients who cannot receive platinum-based chemotherapy. The focus is on individuals with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Participants are divided into two study arms to compare …
This study investigates the safety and effectiveness of an investigational medication combined with high-dose ifosfamide in treating children and adults with relapsed or refractory sarcomas. The investigational medication is known to inhibit certain proteins, such as MET and VEGFR2, which are involved in tumor growth. The purpose of the study …
This study investigates how genetic testing can guide cancer treatment choices for patients with advanced solid tumors. The purpose is to use the genetic information from patients' tumor cells to match them with investigational combination therapies that target specific genetic mutations. This approach aims to control tumor growth and improve …
This study investigates the effects of an investigational medication in combination with chemotherapy for adults with newly diagnosed FLT3-ITD negative acute myeloid leukemia (AML). This trial will compare the investigational medication to a placebo to see if it improves overall survival in these patients.Participants will receive either the investigational medication …
This study investigates hematologic malignancies. The purpose of this study is to assess the safety and feasibility of using autologous anti-CD45 CAR T cells in combination with CD45 base edited hematopoietic stem and progenitor cells.The study evaluates the effectiveness and safety of these treatments in patients who have relapsed or …
This study investigates the safety and effectiveness of an investigational medication in patients with advanced blood cancers, including Non-Hodgkin Lymphoma, Multiple Myeloma, Acute Myeloid Leukemia, and high-risk Myelodysplastic Syndrome.Participants in the study will receive the investigational medication either alone or in combination with other treatments. The study will monitor the …
This study investigates the safety, tolerability, and effects of an investigational medication in individuals with blood cancers that have not responded to previous treatments. The purpose of this study is to determine how well the investigational medication works when used alone or in combination with other anticancer agents. Participants will …
This study investigates providing access to an investigational medication for patients with serious or life-threatening conditions where standard treatments are not suitable. The study focuses on patients with out-of-specification leukapheresis products or out-of-specification manufactured cells for treatment. Leukapheresis is a procedure that involves removing white blood cells from the body, …
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