Found 19 Birth Defects trials
A listing of Birth Defects medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
Phase 3
The first purpose of this study is to test the safety of the addition of a drug called inotuzumab to the usual chemotherapy drugs used for adolescent young adults (ages 18-39). Inotuzumab is investigational and is not FDA-approved. Additionally,this study is to compare any good and bad effects of using …
Changes in the Lymphatic System on the MR Lymphangiography (MRL) In Patients with Liver Cirrhosis
Phase 1
This is an observational study that will compare the differences in lymphatic flow and anatomy of the central lymphatic system on MRL in the liver cirrhosis patients with and without ascites. In the second part of the study, MRL anatomical and flow changes in the central lymphatic system of patients …
Penn Uterine Transplantation for Uterine Factor Infertility (UNTIL) Trial
The UNTIL Trial is a new clinical research trial that offers uterine transplantation to women with uterine factor infertility (UFI). Participation in this trial requires going through an extensive selection process, creation of embryos through in vitro fertilization, and multiple surgeries. Study participants may remain in the study for 5-10 …
ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk
For subjects age 18 years and older who are at an increased risk for HCC and for whom HCC surveillance is appropriate, including subjects with cirrhosis or non-cirrhotic subjects with Hepatitis B. Approximately 3,000 subjects are expected to be enrolled, comprised of approximately 2,222 ultrasound surveillance subjects and 778 subjects …
Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients
Primary Objectives: 1. To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort. 2. To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive. 3. To establish the prevalence of subtypes of …
Predicting Epilepsy Surgery Outcomes Using Neural Network Architecture
The purpose of this study is to test, in surgery patients and controls aged 18 to 65, whether measurable abnormalities found in pre-surgical MRI can predict surgical outcomes in epilepsy, to improve the understanding for the causes of surgical failure, and to pave the way for future use of neuroimaging …
FACT-CRT: Factors Associated with Response to Cardiac Resynchronization Therapy in Heart Failure Patients with Non-LBBB ECG Pattern
This research study seeks to validate how echocardiogram (echo) data predicts response to cardiac resynchronization therapy (CRT) provided by a CRT device with a defibrillator (CRT-D) in individuals without the heart arrhythmia abnormality left bundle branch block (LBBB). It also aims to identify new variables recorded from electrocardiograms (ECG) or …
Cardiotoxicity in Non-metastatic Lung Cancer Patients Treated with Chemoradiation Therapy: A Prospective Longitudinal Cohort
We propose a prospective longitudinal cohort of radiation therapy cardiotoxicity in in patients with locally advanced non-small cell lung cancer treated with definitive chemoradiation. We will enroll patients prior to start of chemoradiation and follow them with echocardiogram, PET/CT stress test, blood draw, and symptoms/activity surveys for 2 years to …
Randomized Controlled Trial of Budesonide + Surfactant
Phase 3
This is a randomized, masked, multicenter clinical trial with allocation to two treatment arms with early intratracheal administration of a combination of budesonide with surfactant (Intervention), as compared to surfactant alone (Control) to reduce the incidence of physiologic bronchopulmonary dysplasia (BPD) in extremely preterm infants. To be included, the infant …
Recursion
This is a multi-center, randomized, double-blind, placebo-controlled study to investigate the safety, efficacy and pharmacokinetics of REC-0000994 compared to placebo in subjects with symptomatic cerebral cavernous malformation (CCM) over a treatment period of 12 months
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