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Found 143 Metastatic Cancer trials

A listing of Metastatic Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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18 years or above
Male
Phase 3
Interventional
This study investigates the effectiveness of adding enhanced therapy to standard treatment for prostate cancer patients experiencing biochemical recurrence. The study aims to compare standard prostate radiation therapy combined with short-term androgen deprivation to an enhanced therapy regimen that includes additional medications. Another aspect of the study examines the use …
99 years or below
All genders
The purpose of this study is to determine surgical outcomes following surgical excision (MMS vs WLE) of cutaneous desmoplastic/spindle cell squamous cell carcinoma. The primary objective of this study is to determine local recurrence rates following surgical excision of cutaneous desmoplastic/spindle cell squamous cell carcinoma. Secondary objectives are to determine …
99 years or below
All genders
PURPOSE We would like to accrue patients consecutively over a several year period in order to collect tissue from many histopathologic subsets of nervous system tumors. Primary brain tumors occur nationally at a rate of approximately 17,000 new cases annually and within this group there are numerous subtypes. At the …
99 years or below
All genders
This study investigates the use of FAPI-74 PET/CT in adults with gastric or esophageal cancer. The purpose is to explore the diagnostic performance of this imaging technique.The study focuses on evaluating how well FAPI-74 PET/CT detects metastatic disease in these conditions. It assesses the effectiveness and accuracy of this imaging …
UPCC 16121 Saci-IO TNBC: Randomized Phase II Study of Sacituzumab Govitecan With or Without Pembrolizumab in PD-L1-Negative Metastatic Triple Negative Breast Cancer (TNBC)
18 years or above
All genders
Phase 2
Interventional
This study investigates the safety and effectiveness of an investigational treatment for patients with metastatic triple-negative breast cancer (TNBC) that is PD-L1-negative. The purpose of this study is to evaluate Sacituzumab Govitecan, alone or in combination with Pembrolizumab, in delaying the progression of this cancer.Participants will undergo various study procedures, …
18 years or above
All genders
Phase 2
Interventional
This study investigates an investigational medication for patients with HER2-positive metastatic breast cancer. The purpose of this study is to evaluate the effects of this investigational medication in patients who have previously been treated with a specific therapy called T-DXd.Participants in this study will receive the investigational medication through an …
18 years or above
All genders
Observational
This study investigates the effectiveness of a quantitative HER2 assay in distinguishing between patients with HER2 IHC1+ metastatic breast cancer who respond to treatment and those who do not. The purpose is to determine if this assay can reliably identify patients who are likely to benefit from receiving investigational medications …
UPCC 04219 Phase 2 Study of Capecitabine-Temozolomide(CapTem) with yttrium-90 Radioembolization in the Treatment of Patients with Unresectable Metastatic Grade 2/3 Neuroendocrine Tumors
18 years or above
All genders
Phase 2
Interventional
This study investigates the treatment of patients with unresectable metastatic neuroendocrine tumors (NETs) that are primarily located in the liver. The purpose of this study is to evaluate the effectiveness and safety of a combination treatment using Capecitabine-Temozolomide (CapTem) and yttrium-90 (Y90) radioembolization.Participants in the study will receive CapTem, which …
18 years or above
All genders
Phase 1
Interventional
This study investigates the safety and effectiveness of an investigational medication, either alone or with standard cancer treatments, in patients with advanced solid tumors, including urothelial cancer, that have a change in the FGFR3 gene. The purpose of this study is to learn more about how the investigational medication works …
18 years or above
All genders
Phase 3
Interventional
This study investigates the effectiveness and safety of using Tumor Treating Fields (TTFields) in combination with pembrolizumab and platinum-based chemotherapy for treating metastatic non-small cell lung cancer (NSCLC). The purpose of this study is to assess how well patients survive overall and how long they live without the disease getting …
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