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Found 180 medicine trials

A listing of medicine medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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99 years or below
All genders
3 OBJECTIVES AND ENDPOINTSPrimary and secondary outcomes will be assessed using routinely collected electronic health record data at Penn Medicine Princeton Medical Center, Pennsylvania Hospital, and Penn Medicine Lancaster General Hospital. Exploratory outcomes will be assessed among those consenting to correlative analyses using additional data collected from participant step count …
NAC Attack: Phase III  Multicenter  Randomized  Parallel  Double Masked  Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients with Retinitis Pigmentosa
18 years - 99 years
All genders
Phase 3
Currently, this study is recruiting among patients at Penn Medicine. It is not accepting non-Penn Medicine patient participants.The objective of the study will be to evaluate the efficacy and safety of oral N-acetylcysteine (NAC) in patients with retinitis pigmentosa (RP). The study is a multi-center, randomized, placebo-controlled study where adult …
Understanding the Genetics of Central Centrifugal Cicatricial Alopecia
99 years or below
All genders
The purpose of this study is to characterize gene mutations associated Central Centrifugal Cicatricial Alopecia (CCCA). The Penn Medicine BioBank (PMBB) supports researchers by providing centralized access to a large number of annotated blood and tissue samples. Clinician identified patients with CCCA and appropriate controls will be recruited from the …
UPCC 02110 I-SPY 2 TRIAL (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And Molecular Analysis 2)
18 years or above
All genders
Phase 2
Interventional
This study investigates personalized medicine approaches to determine which investigational medications are most effective for different types of breast cancer tumors. The purpose is to identify early indicators of treatment response, such as tumor analysis before surgery using MRI images, tissue, and blood samples, to predict treatment success.Participants will undergo …
18 years or above
Male
Phase 3
Interventional
This study investigates metastatic castration-resistant prostate cancer (mCRPC). The purpose of this study is to compare the effectiveness of an investigational medication, ifinatamab deruxtecan, against standard chemotherapy in extending the lives of participants and delaying cancer progression.Participants in the study will receive either the investigational medication or chemotherapy. The study …
99 years or below
All genders
In this secondary use protocol, we will analyze de-identified data from a funded VA study called the Veterans Affairs Multi-omic Platform for Prostate Cancer (VA-MAPP) shared with our team through a fully executed data use agreement with the Greater Los Angeles VA and Penn Medicine to study the genetics of …
TEGSEDI Administration in Patients with Polyneuropathy of Hereditary Transthyretin-mediated Amyloidosis (hATTR-PN)
18 years - 99 years
All genders
Phase 4
TEGSEDI (also known as inotersen) is a medicine that has been approved in the United States, Europe and Canada to treat polyneuropathy (nerve damage) caused by hereditary transthyretin amyloidosis (hATTR-PN) in adults. hATTR-PN is a rare genetic disease that worsens over time if left untreated. This research study will examine …
INFINITY-Prospective Cohort Study of Mechanistic Associations between Intra-Myocardial Fat Deposition and Ventricular Tachycardia in Ischemic Cardiomyopathy
18 years - 99 years
All genders
This study will focus on fat buildup inside the heart muscle, a newly recognized factor that makes patients vulnerable to such fast heart rates, or ventricular tachycardia, after a heart attack. This work may identify more successful strategies for curing dangerously fast heart rates. Adult subjects with prior history of …
TRILOGY
18 years - 65 years
All genders
The target population are patients at Penn Medicine undergoing elective bariatric surgery; and are additionally participating in POW-R study ( Protocol #843280) Patients will be recruited to undergo liver wedge and visceral adipose tissue biopsy and provide blood samples. Liver samples will be processed for RNA, metabolomics, and biochemical and …
JAGUAR- ObJective Analysis to GaUge EVAR Outcomes Through Randomization
21 years - 99 years
All genders
Phase 4
This post-approval study will collect safety, performance, effectiveness, and neck dilatation data on Alto Abdominal Stent Graft System for the endovascular treatment of infrarenal abdominal aortic aneurysms and evaluate real-world outcomes in comparison to commercially available comparator devices. Penn Medicine patients with the Alto Abdominal Stent Graft System, a device …
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