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Found 180 medicine trials
A listing of medicine medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the effectiveness and safety of the Cordella PA Sensor System in patients with NYHA Class III Heart Failure. The purpose of this study is to compare the outcomes of using this system against a set performance goal.This study evaluates how well the Cordella PA Sensor System works …
This study investigates calcific aortic valve stenosis. The purpose of this study is to evaluate if the investigational medication slows the progression of this condition in adults.The study will focus on evaluating the safety, tolerability, and how the investigational medication is processed in the body. It will also look at …
This study investigates genetic and familial dilated cardiomyopathy (DCM).The study evaluates the safety and effectiveness of an investigational medication compared to a placebo.Who can participate: Adults diagnosed with genetic or familial DCM, with stable symptoms and certain heart function criteria, may participate. Participants should not have DCM due to other …
Currently, there are no approved evidence-based medicines for the treatment of symptoms in patients with nHCM. In the absence of proven therapies for the treatment of symptomatic patients with nHCM, this study employs a randomized, placebo-controlled, parallel-group design evaluating ninerafaxstat added to the standard of care (SoC) to maintain clinical …
This study is being performed to evaluate the Thermedical SERF Ablation System to reach intractable, deep circuits supporting recurrent VT. Due to the limitations of VT success rates, such as unable to ablate clinical VT circuits in 10% or more of subjects and the recurrence for VT in 50% or …
The objectives of the Randomized Arm are 1) Demonstrate improvement in survival when non-inotrope dependent advanced HF patients are treated with the HM3 left ventricular assist system (LVAS) compared to being managed on medical therapy alone; and 2) To establish an objective disease-state criteria to trigger referral for a HM3 …
The study has two treatment arms: conventional voltage mapping and ablation (control arm) and isochronal late activation mapping (ILAM) and ablation (investigational arm). This is a multicenter, prospective, parallel, randomized controlled trial to test for non-inferiority with an ILAM-guided VT ablation compared to conventional voltage- based ablation.
The purpose of this study is to characterize the safety and effectiveness of the Sphere-9 Catheter and Affera Ablation System, when used in conjunction with the Affera Mapping System or Affera Integrated Mapping System, in patients undergoing redo ablation for symptomatic recurrent paroxysmal or persistent atrial fibrillation after a single …
This trial will evaluate a noninvasive deep brain stimulation intervention for fibromyalgia. Low-intensity transcranial focused ultrasound (FUS) is delivered to the cingulate cortex using a novel device, DIADEM. The DIADEM system is capable of delivering a known dose of ultrasound with high spatial and temporal precision, thereby modulating the activity …
The objective of this study is to assess the safety and efficacy of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI. Eligible patients approved by the Patient Screening Committee (PSC) will be randomized to undergo HRPCI with either the Supira System (investigational device) or the …
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