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Found 389 oncology trials
A listing of oncology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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Lynch syndrome (LS) is a cancer predisposition syndrome that results from a pathogenic germline mutation in one of five genes, including MLH1, MSH2, MSH6, PMS2, and EPCAM, which are involved in DNA mismatch repair (MMR). Individuals with Lynch syndrome develop cancer at a substantially higher rate than individuals without LS …
This study investigates the effectiveness and safety of an investigational medication combined with pembrolizumab compared to a treatment of the physician's choice in patients with triple negative breast cancer. The purpose is to evaluate these treatments in patients who still have invasive disease after surgery and pre-surgical therapy.Participants will receive …
This study investigates the treatment of Gastrointestinal Stromal Tumors (GIST).The study evaluates the effectiveness and safety of an investigational medication compared to sunitinib in adults whose GIST has spread or cannot be removed by surgery.Who can participate: Adults with metastatic or surgically unresectable GIST who have progressed on or are …
The purpose of this study is to investigate the safety and effectiveness of active surveillance compared to immediate intervention for patients with small kidney tumors. This study will compare two approaches: monitoring the tumor over time or treating it right away.Participants in the study will be divided into two study …
This study investigates the safety and tolerability of an investigational medication for women with hormone receptor-positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer. The study focuses on participants whose tumors have mutations in the PIK3CA gene. The purpose is to find the safest and …
This study investigates the safety, tolerability, and effectiveness of an investigational medication combined with pembrolizumab in individuals with advanced solid tumors. The purpose of this study is to identify the best doses for future research and to understand how the body processes and responds to the treatment.Participants will receive the …
This study investigates the effects of using investigational medications to target minimal residual disease in patients with breast cancer. The purpose of this study is to see if the investigational medications can reduce or eliminate disseminated tumor cells in the bone marrow.Participants in this study will take investigational medications in …
This study investigates the presence of disseminated tumor cells (DTCs) in women who have completed treatment for primary breast cancer within the last five years and are at increased risk of relapse. The purpose is to identify markers that could indicate the likelihood of breast cancer returning. This study will …
This study investigates early-stage triple-negative breast cancer (TNBC) and the effects of observation versus continued immunotherapy after achieving a complete response to initial treatments. The study aims to determine if observation alone can provide similar outcomes to further treatment with an investigational medication after surgery.Participants will be divided into two …
To acquire baseline and serial HCC cancer core biopsy samples in order to characterize the epigenetic, proteomic, metabolomic and immunologic profile of hepatocellular carcinoma cells surviving TACE. See section 2 of full protocol. See section 3.2 full protocol. See section 3.3 full protocol.
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