Found 390 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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The objective of this study is to identify families and individuals with tumors and characterize inherited genetic variation. The outcome of the study is the identification of novel high and low penetrance cancer susceptibility alleles. This is expected to significantly advance our knowledge of the development of cancer and has …
This study investigates the effectiveness of adding adjuvant chemotherapy to ovarian function suppression and endocrine therapy in premenopausal patients with early-stage, estrogen receptor-positive, HER2-negative breast cancer. The study focuses on patients with specific Oncotype recurrence scores, which help predict the risk of cancer returning.Participants in the study will receive ovarian …
This study investigates the safety and effectiveness of adding RP2, an investigational treatment, to the standard chemotherapy regimen, FLOT, for patients with stage II or higher, non-metastatic gastroesophageal adenocarcinoma. The purpose of this study is to determine if injecting RP2 directly into the tumors of the stomach and esophagus, combined …
3 OBJECTIVES AND ENDPOINTSPrimary and secondary outcomes will be assessed using routinely collected electronic health record data at Penn Medicine Princeton Medical Center, Pennsylvania Hospital, and Penn Medicine Lancaster General Hospital. Exploratory outcomes will be assessed among those consenting to correlative analyses using additional data collected from participant step count …
This study investigates the use of an investigational medication for individuals with metastatic castration-resistant prostate cancer. The purpose of this study is to understand the safety and effectiveness of the investigational medication when given alone or in combination with another investigational drug. The study is divided into two parts: Part …
This study investigates the combination of an investigational medication, administered as telomelysin (OBP-301), with pembrolizumab in patients with advanced or metastatic gastric or gastroesophageal junction cancer. The purpose of this study is to determine if this combination is safe and effective for patients whose cancer has progressed despite previous treatments.Participants …
This study investigates the effects of investigational medications like hydroxychloroquine and avelumab, with or without palbociclib, on early-stage ER+ breast cancer patients. These patients have disseminated tumor cells (DTCs) in their bone marrow after surgery and standard therapy. The purpose is to understand how these medications can target DTCs, which …
This study investigates the use of a radiation boost in combination with immune checkpoint blockade therapy in patients with operable breast cancer. The purpose is to determine if combining pembrolizumab, an immune therapy, with a single radiation boost is feasible and effective. The study will track changes in tumor size …
This study investigates the effectiveness of combining hormone therapy with or without an investigational medication in treating patients with breast cancer. Hormone therapies like tamoxifen citrate and others work by lowering estrogen levels, potentially slowing or stopping cancer growth. The investigational medication being studied may also stop tumor growth by …
The goal of the eREACH3 Study is to evaluate the implementation of digital tools into remote genetic services, evaluating uptake and use of digital tools and outcomes in representative clinical populations. Our primary endpoints will include uptake of services and digital alternatives (future amendments). We will use proportions and 95% …
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