Found 390 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the effects of total ablative therapy compared to usual systemic therapy in patients with limited metastatic colorectal cancer. Colorectal cancer can spread to other parts of the body, and this study focuses on cases where it has spread to up to four sites. Ablative therapy aims to …
This study investigates the effects of two investigational treatments for patients with differentiated thyroid cancer that does not respond to standard treatment and has a specific genetic change called BRAF V600E mutation. The purpose of this study is to compare the effectiveness and safety of cabozantinib, a receptor tyrosine kinase …
This study investigates ovarian cancer. The purpose of this study is to compare the investigational medication, Sofetabart Mipitecan, with standard chemotherapy or other treatments for ovarian cancer.The study evaluates the effectiveness and safety of Sofetabart Mipitecan in treating ovarian cancer compared to current standard treatments.Who can participate: Participants must be …
The purpose of this study is to investigate the effect of adding an investigational medication to the immunotherapy drug durvalumab in patients with non-small cell lung cancer (NSCLC) who have undergone chemotherapy and surgery. The study aims to see if the combination of treatments can increase the time patients remain …
This study investigates ways to help adults who survived cancer as children or young adults to reconnect with their healthcare providers for follow-up care. The purpose of this study is to compare the use of a conversational agent, "Penny," with usual care methods. "Penny" is a chatbot designed to communicate …
This study investigates the safety and effectiveness of an investigational oral medication designed to degrade SMARCA2 in patients with advanced or metastatic solid tumors that have a SMARCA4 mutation. The purpose of this study is to understand how the investigational medication affects the body, how it is processed by the …
This study investigates how effective one year versus two years of maintenance therapy is for patients with advanced ovarian cancer that has BRCA1/2 mutations or is homologous recombination deficient (HRD+). The purpose is to compare the effects of using the investigational medication, olaparib, with or without an antiangiogenic agent, bevacizumab, …
This study compares the impact of using a combination of drugs, ramucirumab and pembrolizumab, versus standard chemotherapy for treating advanced non-small cell lung cancer that is stage IV or recurrent. Ramucirumab blocks new blood vessel growth that tumors need, while pembrolizumab boosts the immune system to fight cancer. The trial …
This study investigates the effectiveness of an investigational medication combined with ipilimumab in patients with metastatic pancreatic cancer. The purpose is to understand if this combination can slow tumor growth and what side effects may occur. Participants will be placed into two study arms: Arm A will receive the investigational …
This study investigates the use of an investigational oncolytic immunotherapy called RP2 in combination with other treatments for patients with advanced liver and biliary tract cancers. Specifically, it looks at patients with hepatocellular carcinoma (HCC) that cannot be surgically removed or has returned or spread, and biliary tract cancer (BTC) …
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