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Found 205 Type 2 Diabetes Mellitus trials

A listing of Type 2 Diabetes Mellitus medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A phase 3, randomized, double-blind, study of ianalumab (VAY736) versus placebo in addition to eltrombopag in primary immune thrombocytopenia (ITP) patients who failed steroids

99 years and younger
All genders
PURPOSE The overall objective is to demonstrate that the addition of ianalumab (either 3mg/kg or 9mg/kg dosage) to standard care (eltrombopag) is more effective and safer compared to the standard of care (eltrombopag) alone. Primary outcome variable is determined by the time to treatment failure which is in turn determined …
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A phase 2 study of ianalumab (VAY736) in patients with primary immune thrombocytopenia (ITP) previously treated with at least two lines of therapies

99 years and younger
All genders
PURPOSE To evaluate the efficacy of ianalumab (i.e., platelet response 50 G/L) in participants with primary ITP previously treated with at least a corticosteroid and a TPO-RA. A platelet count of 50 G/L at two (or more) consecutive assessments at least 7 days apart between Week 1 Day 1 and …
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BACKBEAT Trial)

99 years and younger
All genders
Investigational Atrioventricular Interval Modulation (AVIM) software will be loaded onto commercially available Pacemakers (PPM), such as the Medtronic Azure/Astra devices. Therefore, the Azure/Astra devices will be considered investigational while the AVIM is present. AVIM therapy is indicated for the reduction of blood pressure in patients with dual PPM and uncontrolled …
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Left vs Left RCT

99 years and younger
All genders
This trial evaluates the effects of His or left bundle branch pacing (LBBP) comparative to biventricular pacing on quality of life, exercise capacity, hospitalization for heart failure, and mortality in patients with HF and conduction system disease. Study population is patients with heart failure with reduced ejection fraction (HFrEF) less …
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BACKBEAT

99 years and younger
All genders
This is a prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel AV interval modulation (AVIM) algorithm downloaded into a previously implanted dual-chamber Medtronic pacemaker. Patients within 90 days of de novo implant of an Astra/Azure pacemaker also having uncontrolled hypertension may be approached for …
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A phase 3, randomized, double-blind study of ianalumab (VAY736) versus placebo in addition to first-line corticosteroids in primary immune thrombocytopenia

99 years and younger
All genders
To demonstrate that the addition of ianalumab to standard first-line corticosteroids prolongs Time to Treatment Failure compared to Corticosteroids alone in participants with primary ITP. ITP means immune thrombocytopenia. Time from randomization to treatment failure which is defined as Platelet count below 30G/L after 8 weeks from randomization. Need for …
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COLT

99 years and younger
All genders
We are requesting a reliance agreement with the University of Washington Human Subjects Division. The purpose of this study is to determine the safety and efficacy of two doses of CMV-MVA Triplex vaccine pre-transplant. The target population is CMV seronegative prospective liver transplant recipients. The main study interventions are pre-transplant …
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PrEP Implementation for Black Primary Care Patients

99 years and younger
All genders
The overarching goal of this proposal is to facilitate Dr. Watsons long-term goal to become an independent investigator focused on the development of implementation strategies to achieve equitable HIV prevention outcomes among Black populations. The results of this study will be important for the field of implementation science as it …
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ALATHEA

99 years and younger
All genders
To evaluate the effects of VLX-1005 compared to placebo on platelet count recovery, an important clinical outcome in patients with positive serotonin release assay (SRA+) confirmed HIT, on a background of standard of care (SoC) anticoagulation -To evaluate the effects of VLX-1005 compared to placebo on platelet count recovery, an …
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The SAK HFpEF Trial

99 years and younger
All genders
1.Compare the impact on submaximal exercise endurance of Empa, with and without KNO3, as compared to active control (Potassium Chloride, KCl).2.Assess the impact of Empa, with and without KNO3, on SkM OxPhos using novel in vivo MRI-based imaging techniques that quantify SkM OxPhos and intramuscular perfusion with exercise3.Assess the impact …
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