Found 67 hematology trials
A listing of hematology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the safety and effectiveness of two investigational medications in treating HER2-negative metastatic breast cancer. The study involves two investigational medications given in sequence, either trastuzumab deruxtecan followed by datopotamab deruxtecan or vice versa, to understand if this approach works for patients who have already tried other similar …
The objective of this study is to establish a registry of patients with thalassemia to allow for both cross-sectional and longitudinal assessment of laboratory values and outcomes and to compare how different treatments impact these variables. Patients with a diagnosis of a clinically significant alpha or beta thalassemia syndrome who …
This study aims to determine the long-term effects of CTL019 on patients who were enrolled in UPCC 13413: "Phase IIa Study of Redirected Autologous T-Cells Engineered to Contain Anti-CD 19 Attached to TCR and 4- BB Signaling Domains in Patients with Chemotherapy Relapsed of Refractory CD 19+ Lymphomas". It also …
This study investigates an investigational therapy for treating HIV-associated aggressive B-cell non-Hodgkin lymphoma that has either returned or not responded to previous treatments. The purpose is to evaluate the safety and feasibility of using genetically modified T cells, known as CAR-T therapy, which are designed to target a specific protein …
Identification of actionable genetic alterations is critical to determining the appropriate therapy in unresectable non-small cell lung cancer (NSCLC). Red blood cells (RBCs) may be an abundant and long-lasting reservoir of detectable tumor DNA. A "liquid biopsy," using blood samples from patients with advanced NSCLC to identify targetable mutations from …
In this secondary use protocol, we will analyze de-identified data from a funded VA study called the Veterans Affairs Multi-omic Platform for Prostate Cancer (VA-MAPP) shared with our team through a fully executed data use agreement with the Greater Los Angeles VA and Penn Medicine to study the genetics of …
The purpose of this study is to investigate relapsed or refractory multiple myeloma. It evaluates the effects of combining inobrodib with pomalidomide and dexamethasone.This study evaluates the safety and effectiveness of the investigational medication inobrodib when used with other medicines. It looks at how the combination affects patients with the …
The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd in multiple myeloma patients.
Featured study
We are looking for healthy volunteers to donate bone marrow for research purposes. The Stem Cell & Xenograft Core provides bone marrow to laboratories on Penn’s campus researching leukemia and other blood disorders
This study investigates the safety and feasibility of using T-cell receptor engineered donor T-cells in patients undergoing allogeneic peripheral blood stem cell transplantation. The study focuses on patients with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or acute lymphoblastic leukemia (ALL) who receive transplants from specific types of donors. The …
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