Found 40 cardiology trials
A listing of cardiology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This is a Phase III, multi-centre, randomised, double-blind, parallel-group, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death …
This is a global, multicenter, prospective, observational study designed to document clinical characteristics and treatment patterns of adult patients with ATTR-CM treated with vutrisiran or other approved ATTR-CM treatments and to evaluate long-term effectiveness of vutrisiran compared to other approved ATTR-CM treatments. Data will be collected retrospectively and prospectively from …
This is an interventional, randomised, multinational, multicentre, two arm parallel-group, double-blind study. The aim of this study is to evaluate the effect of NNC6019-0001 4800 mg versus placebo in participants with variant or wild-type transthyretin (TTR) amyloid cardiomyopathy (ATTRv-CM or ATTRwt-CM, respectively)
This is a prospective, multi-center, randomized, indication expansion investigational device exemption study. This study will look at the safety and effectiveness of left bundle branch area pacing (LBBAP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle branch block (LBBB) with an indication for a cardiac …
The purpose of this study is to evaluate the efficacy and safety of concomitant use of eplontersen and ALXN2220 compared with eplontersen and placebo in adult participants with ATTR-CM who are treated with standard-of-care therapy as determined by the treating and study physician(s). The study duration will be up to …
Study AG10-404 is a single-arm, prospective, longitudinal, open-label study to investigate the long-term effects of acoramidis on improving cardiac function and structure, and on cardiac amyloid burden in participants with transthyretin amyloid cardiomyopathy (ATTR-CM) over 36 months using two well-established, complementary imaging modalities - cardiac echocardiography and cardiac magnetic resonance …
Open-label, multi-center, international, prospective, single-arm, study to obtain market approval for the LivIQ system. Patients with a class I or II indication for ventricular pacing (VVI/VDD), Bradycardia (slow heart rate) will be enrolled in the study. LivIQ VR-T DX is a leadless pacemaker, is an investigational device that can sense …
The study is a prospective, randomized, controlled, multi-center, premarket study in patients with Persistent Atrial Fibrillation (PsAF) undergoing first-time catheter ablation with the VARIPULSE Catheter System. Participants in the study will be randomized into one of two arms: Arm 1: PVI and SVCI Arm 2: PVI and SVCI + PWI …
DPP4 is an enzyme that breaks down proteins that may affect blood sugar and the heart. We will recruit individuals from the Penn Biobank (cases, controls). Participants will be asked to complete a meal test, DXA, and echocardiogram with exercise. A cardiac MRI and related pilot study are optional.
This study will focus on fat buildup inside the heart muscle, a newly recognized factor that makes patients vulnerable to such fast heart rates, or ventricular tachycardia, after a heart attack. This work may identify more successful strategies for curing dangerously fast heart rates. Adult subjects with prior history of …
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