Found 390 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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Study of Investigational Medication in Patients with Advanced Cancers that Form in Organs or Tissues
This study investigates an investigational medication in patients with advanced or metastatic solid tumors. The purpose of the study is to evaluate the safety, tolerability, and dose-limiting toxicities (DLTs) of the investigational medication. The study will also determine the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE) in …
This study investigates the safety and pharmacokinetics of an investigational medication, ROSE12, in patients with locally advanced or metastatic solid tumors. The study is conducted in three parts: a dose-escalation part to determine the safe dose, a biopsy part to evaluate biomarkers, and an expansion part to further assess the …
This study investigates personalized medicine approaches to determine which investigational medications are most effective for different types of breast cancer tumors. The purpose is to identify early indicators of treatment response, such as tumor analysis before surgery using MRI images, tissue, and blood samples, to predict treatment success.Participants will undergo …
This study investigates the safety and effects of an investigational medication in participants with advanced solid tumors. The purpose of this study is to find the right dose of the investigational medication and to see how well it works in treating these tumors. Participants will have recurrent or metastatic solid …
This study investigates how genetic testing can guide cancer treatment choices for patients with advanced solid tumors. The purpose is to use the genetic information from patients' tumor cells to match them with investigational combination therapies that target specific genetic mutations. This approach aims to control tumor growth and improve …
This study investigates the safety and effectiveness of an investigational medication combined with high-dose ifosfamide in treating children and adults with relapsed or refractory sarcomas. The investigational medication is known to inhibit certain proteins, such as MET and VEGFR2, which are involved in tumor growth. The purpose of the study …
This study investigates the use of an investigational medication, a monoclonal antibody targeting Tumor Necrosis Factor Receptor 2 (TNFR2), in people with advanced malignancies. The purpose of the study is to evaluate the safety and tolerability of the investigational medication both alone and in combination with pembrolizumab, a type of …
This study investigates the safety and clinical activity of an investigational medication in participants with advanced solid tumors that have a specific genetic mutation known as KRAS G12C. The purpose of this study is to evaluate how the investigational medication works in different phases, including dose escalation and expansion, to …
This study investigates the effects of an investigational medication on patients with advanced solid tumors that have a KRAS G12D mutation. The purpose is to understand the safety and effectiveness of the investigational medication when used alone and in combination with other treatments.Participants in the study will receive the investigational …
PURPOSE: The objectives of the study are to recruit patients with GI NETs and to develop an annotated database including biosamples for use by our research group including biosamples to facilitate better understanding of the genetics and biochemical signaling pathways leading to tumor formation and malignancy. Our first project is …
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