Found 390 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates an investigational medication for patients with HER2-positive metastatic breast cancer. The purpose of this study is to evaluate the effects of this investigational medication in patients who have previously been treated with a specific therapy called T-DXd.Participants in this study will receive the investigational medication through an …
This study investigates an imaging technique using an investigational medication and a special camera system to detect cancer in patients undergoing surgery for endometrial cancer. The purpose of this study is to assess how well the investigational medication works when used with this imaging technique during surgery.Participants will undergo several …
This is an investigator-initiated, open label phase Ib study examining 2nd line atezolizumab and tocilizumab in a cohort of recurrent/metastatic non-small cell lung cancer patients who have received prior immune checkpoint inhibitor therapy with or without other forms of therapy (i.e. chemotherapy, radiation). Patients with driver mutations in EGFR, ALK, …
This study investigates the effectiveness of letrozole, an investigational medication, in comparison to a placebo for postmenopausal women with hormone receptor-positive breast cancer. The purpose of this study is to determine if taking letrozole for five years can improve disease-free survival after completing five years of hormonal therapy, which may …
Phase 2: To evaluate BICR-assessed objective response rate at each dose level of R-DXd. Phase 3:To evaluate BICR-assessed objective response rate with R-DXd treatment compared with investigator's choice of paclitaxel, PLD, gemcitabine, or topotecan. Objectives, outcome measures, and endpoints are located in Tables 3.1 and 3.2 of the protocol. Phase …
The purpose of this study is to obtain consent to biobank skin specimens for future research studies. Skin growths, skin cancer, autoimmune or inflammatory skin diseases, and normal skin may be banked. Eligible patients include those who are seen at the University of Pennsylvania Health System clinical practices. For patients …
This study investigates different dosing strategies for CDK4/6 inhibitors in older patients with metastatic breast cancer (MBC). The purpose of the study is to compare standard dosing with a titrated dosing approach to see which helps patients tolerate the medication better and continue treatment longer.Participants will be randomly assigned to …
This study investigates treatments for non-small cell lung cancer (NSCLC) by using a method called genomic screening. The purpose of this study is to determine which type of cancer trait, known as a biomarker, a participant has. This information helps assign participants to different sub-studies within a larger protocol called …
The research study is being conducted to develop a test to predict a common complication after lung transplant called primary graft dysfunction (PGD). Predicting PGD before using donor organs may help reduce deaths and improve outcomes of patients receiving a lung transplant in the future.
This study investigates the treatment of advanced or recurrent endometrial cancer with proficient mismatch repair (pMMR). In pMMR endometrial cancer, certain normal proteins are present in the cancer cells. This condition can be advanced, meaning the cancer has spread beyond the uterus, or recurrent, meaning it has returned after treatment. …
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