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Found 57 Breast Cancer trials

A listing of Breast Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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99 years or below
All genders
This study investigates advanced metastatic breast cancer. The purpose of this study is to explore new treatment options for patients with this condition.The study evaluates the effectiveness and safety of a specific treatment regimen combined with a checkpoint inhibitor. It seeks to understand how these treatments affect overall survival in …
18 years or above
All genders
Phase 3
Interventional
This study investigates the effectiveness of two different radiation therapy approaches, fractionated stereotactic radiosurgery (FSRS) and single fraction stereotactic radiosurgery (SRS), in treating patients with cancer that has spread to the brain. SRS involves delivering a single large dose of radiation to the tumor, while FSRS spreads the dose over …
99 years or below
All genders
Male breast cancer (MBC) is rare, comprising only 1% of all breast malignancies. Due to lack of clinical trial data, treatment of MBC is largely extrapolated from current guidelines on management of female breast cancer (FBC). This study aims to investigate current treatment patterns in MBC. An anonymous online survey …
UPCC 07623 Effect of Immune Checkpoint Inhibitors on Coronary Microvasculature
18 years or above
All genders
Observational
The purpose of this study is to investigate the effects of immune checkpoint inhibitors (ICI) on the heart and circulatory system in patients with breast cancer or non-small cell lung cancer. This study focuses on understanding how these medications, which are used in cancer treatment, might impact heart health. An …
All genders
Phase 2
Interventional
This study investigates how genetic testing can guide cancer treatment choices for patients with advanced solid tumors. The purpose is to use the genetic information from patients' tumor cells to match them with investigational combination therapies that target specific genetic mutations. This approach aims to control tumor growth and improve …
A Randomized, Open-Label, Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy
18 years - 100 years
Female
Phase 3
The goal of this study is to find out if the experimental product, sacituzumab govitecan-hziy (SG) in combination with pembrolizumab given after surgery, is effective and safe compared to the treatment of physician's choice (TPC) which includes either pembrolizumab or pembrolizumab plus capecitabine in participants with triple negative breast cancer …
18 years or above
All genders
Phase 3
Interventional
This study investigates the efficacy and safety of an investigational medication in combination with chemotherapy for treating individuals with metastatic HER2-positive breast cancer. Participants in this study have previously been treated with a specific medication called T-DXd but have either not responded or cannot tolerate it.Participants will be randomly assigned …
18 years - 130 years
All genders
Phase 3
Interventional
The purpose of this study is to investigate the effectiveness and safety of an investigational medication compared to standard endocrine therapy for patients with ER+/HER2- early breast cancer. The study focuses on patients who have completed locoregional treatment, which may include surgery and radiotherapy, and are at intermediate-high or high …
18 years or above
All genders
Interventional
This study investigates the effects of photobiomodulation therapy (PBMT) on chronic lymphedema in survivors of head and neck cancer. PBMT is a type of light therapy that has been approved by the U.S. Food and Drug Administration for treating arm lymphedema related to breast cancer. This study aims to confirm …
99 years or below
All genders
The purpose of this protocol is to send the pre-collected and shelved DNA samples (parent protocol IRB #376800) from patients fitting the study eligibility requirements for genotyping at the Center for Inherited Disease Research (CIDR) at Johns Hopkins University. The samples will be used in genome-wide association studies (GWAS), which …