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Found 57 Breast Cancer trials
A listing of Breast Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the safety and effectiveness of an investigational medication in patients with locally advanced or metastatic solid tumors that have a specific mutation in the TP53 gene called Y220C. The study is divided into different phases to assess the medication alone and in combination with another treatment. The …
This study investigates early-stage triple-negative breast cancer (TNBC) and the effects of observation versus continued immunotherapy after achieving a complete response to initial treatments. The study aims to determine if observation alone can provide similar outcomes to further treatment with an investigational medication after surgery.Participants will be divided into two …
Our overall goal is to discover novel breast cancer therapeutics which target the endocrine and paracrine signaling pathways that are essential to tumor development within the tumor microenvironment Please see Section 2 of the full study protocol Please see Section 2 of the full study protocol.
Please see the full protocol, refer to Section 2, Objectives. Please see the full protocol, Section 3.2.6 Outcomes Data. Please see the full protocol, Section 11, Statistical Considerations.
This study investigates the effectiveness and safety of an investigational medication combined with pembrolizumab compared to a treatment of the physician's choice in patients with triple negative breast cancer. The purpose is to evaluate these treatments in patients who still have invasive disease after surgery and pre-surgical therapy.Participants will receive …
We propose the use of 2 different study populations to first evaluate cancer access outcomes among patients enrolled in IMPaCT who subsequently receive a diagnosis of cancer, compared to University of Pennsylvania Health System administrative data of cancer patients not enrolled in IMPaCT who meet insurance and zipcode criteria; and …
This study investigates digital mindfulness-based interventions for younger breast cancer survivors who experience elevated depressive symptoms. The purpose of this study is to compare two different digital approaches: one that is live and instructor-led via Zoom, and another that is self-paced and app-based. Participants are breast cancer survivors diagnosed at …
This study investigates the use of PET/CT imaging to evaluate the uptake of a special substance called [18F]F-Gln in patients with breast cancer. This study includes patients with known or suspected primary or metastatic breast cancer, which means the cancer may have spread to other parts of the body. The …
This study investigates the safety and effectiveness of two investigational medications in treating HER2-negative metastatic breast cancer. The study involves two investigational medications given in sequence, either trastuzumab deruxtecan followed by datopotamab deruxtecan or vice versa, to understand if this approach works for patients who have already tried other similar …
This study investigates the use of a radiation boost in combination with immune checkpoint blockade therapy in patients with operable breast cancer. The purpose is to determine if combining pembrolizumab, an immune therapy, with a single radiation boost is feasible and effective. The study will track changes in tumor size …
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