Found 33 Depression trials
A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study will evaluate the efficacy and safety of brenipatide vs placebo as an add-on to stable standard of care (SoC) in adults with BD I/II in remission or near remission with residual symptoms. The primary measure is time to relapse. The study includes Screening (~4 weeks), Double-Blind Treatment (until …
We are requesting a reliance agreement with Advarra for a randomized control trial using the ATTN201 device for the treatment of OCD. The ATTN201 device will provide low-intensity focused ultrasound to the subthalamic nucleus (STN). The device is a safe, easy-to-use, helmet-like device meant to be used in-clinic or at …
The dlPFC is increasingly being targeted with TMS to reduce anxiety expression; however, there is little mechanistic evidence supporting treatment. Thus, the objective of the current project is to develop an interleaved TMS/fMRI that can assess the effect of TMS protocols on neural and behavioral measures related to anxiety expression. …
Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS. Exploratory aim: Evaluate changes to resting state spectral dynamics in absence of stimulation after aiTBS
The purpose of this study is to investigate the effects of transcranial magnetic stimulation (TMS) on brain circuits associated with fear and emotional processing in individuals with posttraumatic stress disorder (PTSD). Specifically, investigators aim to determine whether TMS can engage and modulate the amygdala, a brain region implicated in PTSD, …
This dual-site, double-blinded, randomized, sham-controlled, crossover study is to assess the safety, feasibility, and preliminary efficacy of SEEG-guided multi-lead DBS in 10 participants suffering from severe symptoms of chronic, treatment-refractory OCD. Stage 1: Invasive SEEG Monitoring and Recovery Goal: To perform stimulation mapping studies and SEEG recordings, that aid in …
The primary objective of this study is to determine if treatment of the femoral head with core decompression and cell grafting increases the survivorship of the hip when compared to core decompression alone. The secondary objectives are to determine which factors may contribute to the success or failure of these …
The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., machine learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes.
The objectives of this proposal are to: 1) describe the incidence of depression and trajectory of depressive symptoms; 2) identify potential determinants of depression; and 3) characterize the consequences of depression in a large, international cohort of patients with PC and in subgroups of this population during early and late …
This study investigates the use of an investigational medication to treat Adjustment Disorder (AjD) in patients with cancer and other medical conditions such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD), or Idiopathic Pulmonary Fibrosis (IPF). The purpose of this study is to assess whether a single …
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