Found 16 Depression trials
A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
The purpose of this study is to examine how depression symptoms develop when women begin the transition to menopause. This study will investigate depression symptoms by looking at how fluctuations in reproductive hormones (specifically, the hormone estradiol) might impact the body's biological sleep rhythms. This study will also look at …
This research study is being conducted to learn more about how brain stimulation [transcranial magnetic stimulation (TMS)] affects the communication between brain regions. TMS is a new treatment that is starting to be used to treat depression and other psychiatric disorders. However, we do not have a good idea for …
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation
This study aims to determine what underlies the antidepressant effects of sleep deprivation. A novel measure of glutamate imaging, GluCEST, will be used to assess changes in glutamatergic activity following total sleep deprivation.
The purpose of this study is to explore possible neurological complications resulting from prior COVID-19 infection. Neurological symptoms, including ‘brain fog’, depression, and/or anxiety can be disabling. This study aims to determine the prevalence and severity of these symptoms. Unfortunately, little is known about these neuropsychiatric symptoms, particularly in patients …
This is an OL, multicenter, long-term study to evaluate the safety and efficacy of aticaprant 10 mg in combination with an oral antidepressant in adult and elderly participants with MDD and who have had an inadequate response to an SSRI or SNRI in the current depressive episode. Participants will enter …
In this trial, we will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a published study (Williams et al., 2018) demonstrating …
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, we will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each subject. Then, we will …
This dual-site, double-blinded, randomized, sham-controlled, crossover study is to assess the safety, feasibility, and preliminary efficacy of SEEG-guided multi-lead DBS in 10 participants suffering from severe symptoms of chronic, treatment-refractory OCD. Stage 1: Invasive SEEG Monitoring and Recovery Goal: To perform stimulation mapping studies and SEEG recordings, that aid in …
The research study is being conducted to test the efficacy of a new psychotherapeutic strategy, closed loop real time fMRI neurofeedback, in reducing negative attention bias and depressive symptoms. Participants are being asked to voluntarily participate in a research study because they are between the ages 18-65 and currently experiencing …
A randomized, double-blind, placebo-controlled Phase 3 trial of REL-1017 in Major Depressive Disorder (MDD) as an adjunctive therapy
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