Found 24 Liver Disease trials
A listing of Liver Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Effects of NNC0194-0499 alone and in combination with semaglutide, of semaglutide alone, and of cagrilintide alone and in combination with semaglutide on liver damage and alcohol use in people with alcohol-related liver disease
Liver metastases are a leading cause of death among patients with metastatic colorectal cancer. Duration of disease control is short following 2nd-line or later systemic therapy. Liver-directed therapy such as TACE has a higher response rate and improves PFS, but the benefit is still limited. Cancer cells escape ischemic cell …
The goal of study 1 and study 2 is to evaluate the effects of ALN-HSD on liver fibrosis and other histologic features of NASH in participants with NASH and F2/F3 fibrosis and risk alleles for HSD17B13. Necessary screening procedures include blood tests, liver stiffness measurement, study-specific genotype criteria, and a …
There is evidence that GALAD, a score that incorporates 3 blood based biomarkers and patient age and sex may be more effective than standard of care screening at detecting HCC early in patients with liver cirrhosis or chronic hepatitis B. Patients undergoing liver cancer screening will be enrolled, then randomized …
Evaluate the effectiveness of Eye90 treatment in subjects with unresectable HCC. Incidence of adverse events (AEs), grouped by System Organ Class (SOC) and Preferred Term (PT), relatedness to study treatment/procedure, and severity. Incidence of serious adverse events (SAEs), grouped by System Organ Class (SOC) and Preferred Term (PT), relatedness to …
The target population are patients at Penn Medicine undergoing elective bariatric surgery; and are additionally participating in POW-R study ( Protocol #843280) Patients will be recruited to undergo liver wedge and visceral adipose tissue biopsy and provide blood samples. Liver samples will be processed for RNA, metabolomics, and biochemical and …
Primary: To determine the preliminary efficacy of TATE in the locoregional treatment of NET liver metastases using ORR based on Response Evaluation Criteria in Solid Tumors (RECIST) criteria 1.1 and the DoR. Secondary: Determine the toxicity of TATE in NET patients with liver-dominant metastases Determine the PFS by mRECIST and …
The overarching goal of our Clinical Validation Center for Hepatocellular Carcinoma (CVC-HCC) is to develop a robust infrastructure that will support efficient validation of emerging HCC biomarkers. Our CVC-HCC will also conduct studies to validate novel blood and imaging biomarkers to improve risk stratification and early detection in patients with …
We are requesting a reliance agreement with the University of Washington Human Subjects Division. The purpose of this study is to determine the safety and efficacy of two doses of CMV-MVA Triplex vaccine pre-transplant. The target population is CMV seronegative prospective liver transplant recipients. The main study interventions are pre-transplant …
In this study, the Investigators at the University of Pennsylvania will assess organ-specific biomarker profiles (proteins and metabolites), in order to better understand biologic processes, the interplay between the heart and extracardiac organs, and their role in human disease, with an emphasis on cardiovascular disease. The study will specifically focus …
