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Found 16 Inflammation trials

A listing of Inflammation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Evaluating Study Drug BIIB059 in Participants with Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus with or without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)

18-99 years
All genders
Phase 2
Interventional
The research study is being conducted to investigate if the study drug BIIB059 can reduce disease activity and inflammation in people with active Cutaneous Lupus Erythematosus compared to a placebo. Participants will complete the following research procedures: demography and medical history, previous CLE therapy, SARS-CoV-2 (COVID-19) test, chest X-ray, skin …
 PROACTIVE: Study to Evaluate the Efficacy and Safety of PRV-015 in Adult Patients with Non-Responsive Celiac Disease as an Adjunct to a Gluten-free Diet

PROACTIVE: Study to Evaluate the Efficacy and Safety of PRV-015 in Adult Patients with Non-Responsive Celiac Disease as an Adjunct to a Gluten-free Diet

18-70 years
All genders
Phase 2
Approximately 50% of patients with celiac disease have continued symptoms despite at least 12 months of treatment with a gluten free diet. PRV-015, a mAb that blocks IL-15, has been shown to reduce intestinal inflammation and improve clinical symptoms induced by gluten consumption in a previous Phase 2a gluten-challenge study …

PAMPA Study

99 years and younger
All genders
The primary objective of our proposed trial will be to test the hypothesis that a prolonged, unresolved skin inflammation coupled with musculoskeletal power-doppler ultrasound (MSKPDUS) abnormalities driven by IL-23 increase the risk for transition into PsA and that an intervention that targets one of these pivotal molecules (i.e., Guselkumab) will: …

Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients with Light Chain Amyloidosis using Positron Emission Tomography (PET/CT)

99 years and younger
All genders
We plan to enroll up to 25 (target of 20 fully evaluable) adult subjects in this study who have an established diagnosis of advanced cardiac amyloidosis (AL). Subjects will be included in 2 subject cohorts of approximately 10 subjects each. In one cohort positron emission tomography/computed tomography (PET/CT) imaging will …
 DECODE Biologic-Describing the Consequences of Delays in Biologic initiation Study

DECODE Biologic-Describing the Consequences of Delays in Biologic initiation Study

18-99 years
All genders
This study plans to learn more about the usage and effect of biologic medications with patients that have inflammatory bowel disease (IBD). IBD includes both Crohn’s Disease (CD) and Ulcerative Colitis (UC), which currently affects around 1.5 million Americans. Medical therapies for IBD focus on reducing the inflammation of the …
 The International MS Microbiome Study

The International MS Microbiome Study

18-90 years
All genders
Dr. Amit Bar-Or, MD, FRCPC from the University of Pennsylvania Department of Neurology is conducting a study to investigate how the structure and activity of gastrointestinal microbes (bacteria and fungi) found in the gut contribute to multiple sclerosis pathogenesis. You are being asked to participate in this study because either …
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