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Found 38 Small Cell Lung Cancer trials

A listing of Small Cell Lung Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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18 years or above
All genders
Phase 3
Interventional
This study investigates the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment for patients with locally advanced non-small cell lung cancer (NSCLC) that cannot be treated with surgery. The purpose is to see if SBRT, which uses precise radiation to target tumors, can improve outcomes when …
UPCC 03522 A Phase 1/2, Umbrella Study With Rolling Arms of Investigational Agents, With Pembrolizumab With or Without Chemotherapy in Treatment-Naive Participants With Stage IV Non-small Cell Lung Cancer (NSCLC)
18 years or above
All genders
Phase 1/2
Interventional
This study investigates the use of investigational medications in combination with pembrolizumab, with or without chemotherapy, for people with Stage IV non-small cell lung cancer (NSCLC). The purpose of this study is to evaluate the safety and effectiveness of these treatment combinations in participants who have not previously received treatment …
99 years or below
All genders
Phase 1
This is an investigator-initiated, open label phase Ib study examining 2nd line atezolizumab and tocilizumab in a cohort of recurrent/metastatic non-small cell lung cancer patients who have received prior immune checkpoint inhibitor therapy with or without other forms of therapy (i.e. chemotherapy, radiation). Patients with driver mutations in EGFR, ALK, …
99 years or below
All genders
This study investigates non-squamous non-small cell lung cancer. It focuses on patients with advanced or metastatic forms of this condition who have previously been treated and do not have actionable genomic alterations.The study evaluates the effectiveness and tolerability of an investigational medication compared to standard care. It also involves an …
S2302 - Comparing two treatments for advanced lung cancer: one without chemotherapy (using a combination of drugs called ramucirumab and pembrolizumab), and the other following the usual care after immunotherapy
All genders
Phase 3
This study compares the impact of using a combination of drugs, ramucirumab and pembrolizumab, versus standard chemotherapy for treating advanced non-small cell lung cancer that is stage IV or recurrent. Ramucirumab blocks new blood vessel growth that tumors need, while pembrolizumab boosts the immune system to fight cancer. The trial …
18 years or above
All genders
Phase 3
Interventional
The purpose of this study is to investigate the effect of adding an investigational medication to the immunotherapy drug durvalumab in patients with non-small cell lung cancer (NSCLC) who have undergone chemotherapy and surgery. The study aims to see if the combination of treatments can increase the time patients remain …
UPCC 07623 Effect of Immune Checkpoint Inhibitors on Coronary Microvasculature
18 years or above
All genders
Observational
The purpose of this study is to investigate the effects of immune checkpoint inhibitors (ICI) on the heart and circulatory system in patients with breast cancer or non-small cell lung cancer. This study focuses on understanding how these medications, which are used in cancer treatment, might impact heart health. An …
18 years or above
All genders
Phase 2
Interventional
This study investigates the safety, tolerability, and preliminary effectiveness of an investigational medication, either alone or in combination with another treatment, for patients with advanced solid tumors. The study includes patients with specific types of cancer, such as urothelial cancer and non-small cell lung cancer, who have not responded to …
18 years or above
All genders
Phase 1
Interventional
This study investigates the treatment of KRAS-mutated cancers. The purpose of this study is to evaluate the safety and preliminary effectiveness of a new investigational treatment in patients with specific types of cancer that have a KRAS mutation.The study focuses on assessing the safety and how well the investigational treatment …
18 years or above
All genders
Phase 1/2
Interventional
This study investigates the effects of an investigational medication on patients with advanced solid tumors that have a KRAS G12D mutation. The purpose is to understand the safety and effectiveness of the investigational medication when used alone and in combination with other treatments.Participants in the study will receive the investigational …
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