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Found 36 Non-Small Cell Lung Cancer trials
A listing of Non-Small Cell Lung Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the effectiveness of an investigational medication combined with chemotherapy compared to another treatment with chemotherapy for patients with advanced non-small cell lung cancer. The focus is on those with a specific protein expression called PD-L1. The study aims to understand how well the investigational medication works in …
This study investigates the use of an investigational imaging agent for lung cancer surgery. The purpose of this study is to explore the effectiveness and safety of a single dose of a fluorescence imaging agent administered through intravenous infusion. This agent is used during surgical procedures for patients with Stage …
This study investigates the use of investigational medications for treating metastatic non-small cell lung cancer (mNSCLC) in patients whose tumors express PD-L1. The purpose of this study is to compare the effectiveness and safety of two treatments: one investigational medication and a standard treatment, pembrolizumab. Participants will be randomly assigned …
This study investigates the use of investigational medications for treating advanced or metastatic non-small cell lung cancer (NSCLC) with a specific genetic mutation known as KRAS G12C. The purpose of this study is to compare the effects of calderasib, a targeted therapy, combined with subcutaneous pembrolizumab, against a combination of …
This study investigates treatment options for patients with non-small cell lung cancer (NSCLC) that have mutations in the epidermal growth factor receptor (EGFR) gene. Patients in this study have experienced disease progression despite previous treatment with EGFR tyrosine kinase inhibitors, which are medications that block signals promoting cancer cell growth.Participants …
This study investigates treatment options for non-small cell lung cancer (NSCLC), focusing on patients who undergo surgery. The purpose is to determine if adding an investigational medication to pembrolizumab post-surgery is more effective in preventing disease recurrence in patients who did not achieve a pathological complete response (pCR) after initial …
This study investigates the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment for patients with locally advanced non-small cell lung cancer (NSCLC) that cannot be treated with surgery. The purpose is to see if SBRT, which uses precise radiation to target tumors, can improve outcomes when …
Identification of actionable genetic alterations is critical to determining the appropriate therapy in unresectable non-small cell lung cancer (NSCLC). Red blood cells (RBCs) may be an abundant and long-lasting reservoir of detectable tumor DNA. A "liquid biopsy," using blood samples from patients with advanced NSCLC to identify targetable mutations from …
This is an investigator-initiated, open label phase Ib study examining 2nd line atezolizumab and tocilizumab in a cohort of recurrent/metastatic non-small cell lung cancer patients who have received prior immune checkpoint inhibitor therapy with or without other forms of therapy (i.e. chemotherapy, radiation). Patients with driver mutations in EGFR, ALK, …
This study investigates the treatment of KRAS-mutated cancers. The purpose of this study is to evaluate the safety and preliminary effectiveness of a new investigational treatment in patients with specific types of cancer that have a KRAS mutation.The study focuses on assessing the safety and how well the investigational treatment …
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