Found 14 Amyloidosis trials
A listing of Amyloidosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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Specific Aims include: Coordinate all human PET and MR imaging at U Penn, UCSF, Yale and WU. Standardize inclusion/exclusion criteria for patient groups - idiopathic PD, MSA, PSP, FTD and healthy controls. Harmonize PET scanning protocols and devices. Generate and coordinate all regulatory protocols including local Radiation Safety or Radioactive …
Study AG10-404 is a single-arm, prospective, longitudinal, open-label study to investigate the long-term effects of acoramidis on improving cardiac function and structure, and on cardiac amyloid burden in participants with transthyretin amyloid cardiomyopathy (ATTR-CM) over 36 months using two well-established, complementary imaging modalities - cardiac echocardiography and cardiac magnetic resonance …
To assess the effect of donanemab versus placebo on cognitive and functional progression in participants with established alpha-synuclein and amyloid co-pathology
This is an interventional, randomised, multinational, multicentre, two arm parallel-group, double-blind study. The aim of this study is to evaluate the effect of NNC6019-0001 4800 mg versus placebo in participants with variant or wild-type transthyretin (TTR) amyloid cardiomyopathy (ATTRv-CM or ATTRwt-CM, respectively)
This study investigates the presence of certain brain proteins in people with conditions like Progressive Supranuclear Palsy, Corticobasal Syndrome, genetic Frontotemporal Lobar Degeneration, Parkinson's Disease, Alzheimer's Disease, and healthy individuals. These conditions are collectively known as tauopathies.The study evaluates how a special substance, which can be seen in brain scans, …
This study investigates ATTR amyloidosis with cardiomyopathy. The purpose of this study is to evaluate the effects of an investigational medication compared to a placebo.This study evaluates the safety and effectiveness of the investigational medication on cardiovascular events and patient-reported health status.Who can participate: Adults with a diagnosis of ATTR …
This registry is a retrospective observational, multi-center study designed to collect data and analyze data retrospectively on patients with AL or TTR cardiac amyloidosis. Subjects under the care of the local investigator will be identified and consented. No patient visits or patient procedures will be required for the purpose of …
Primary Objective: To determine changes in neurodegeneration over the first year of treatment with anti-amyloid monoclonal antibodies Secondary Objectives: To identify measures that detect and monitor neuroinflammation during anti-amyloid treatment. To explore the interaction between neuroinflammation and neurodegeneration Primary Endpoint: Neuroimaging and blood-based measures of neurodegeneration, cognitive performance Secondary Endpoints: …
TEGSEDI (also known as inotersen) is a medicine that has been approved in the United States, Europe and Canada to treat polyneuropathy (nerve damage) caused by hereditary transthyretin amyloidosis (hATTR-PN) in adults. hATTR-PN is a rare genetic disease that worsens over time if left untreated. This research study will examine …
This is a prospective global multicenter long-term observational study designed to document the clinical outcomes of patients with hereditary transthyretin-mediated amyloidosis or wild-type transthyretin-mediated amyloidosis and the safety of patisiran (Onpattro) when used in patients with ATTRv amyloidosis. This is data collection study only and no study medication no visits …
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