Found 24 Colorectal Cancer trials
A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the use of an investigational medication in patients with advanced solid tumors, specifically focusing on its effects as a single agent or in combination with other therapies. The purpose is to determine the recommended Phase II dose and to evaluate its safety, tolerability, and anti-tumor activity. The …
Lynch syndrome (LS) is a cancer predisposition syndrome that results from a pathogenic germline mutation in one of five genes, including MLH1, MSH2, MSH6, PMS2, and EPCAM, which are involved in DNA mismatch repair (MMR). Individuals with Lynch syndrome develop cancer at a substantially higher rate than individuals without LS …
This study investigates the effects of combining an investigational medication with another treatment for patients with metastatic colorectal cancer that primarily affects the liver. In this study, researchers are looking at how the combination treatment works and its safety for patients.Participants in the study will receive the investigational medication along …
This study investigates the safety and effectiveness of an investigational medication in combination with immuno-oncology agents for individuals with advanced or metastatic solid tumors that cannot be surgically removed. The purpose of this study is to understand how the investigational medication, when used alone or with other treatments like nivolumab, …
This study investigates the condition of locally advanced or metastatic solid tumors. It evaluates an investigational medication to understand its effects on this particular health issue.The purpose of this study is to evaluate the safety and effectiveness of the investigational medication. It assesses how well the medication is tolerated and …
This study investigates colorectal cancer. The purpose is to compare the investigational medication with the current standard of care.The study evaluates the safety and effectiveness of the investigational medication. It focuses on understanding how well the investigational medication works and its safety profile.Who can participate: Eligibility criteria are to be …
Phase II and III: To compare time to DFS event (recurrence, second primary colorectal cancer or death) in ctDNA (+ve) cohort following resection of colon cancer treated with 5-FU (orcapecitabine) and oxaliplatin x 6 months or 5-FU, oxaliplatin and irinotecan x 6 months.
This study investigates screening methods for pancreatic cancer in individuals who are at high risk due to genetic factors or family history. The purpose of this study is to better understand the effectiveness of these screening methods in detecting early signs of pancreatic cancer.Participants in this study will undergo procedures …
This study investigates the safety and effectiveness of an investigational medication in patients with locally advanced or metastatic solid tumors that have a specific mutation in the TP53 gene called Y220C. The study is divided into different phases to assess the medication alone and in combination with another treatment. The …
This study investigates an investigational medication designed to treat patients with advanced or metastatic solid tumors. The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of this medication both as a standalone treatment and in combination with other agents. The study is focused on …
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