Found 390 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the efficacy and safety of an investigational medication in combination with chemotherapy for treating individuals with metastatic HER2-positive breast cancer. Participants in this study have previously been treated with a specific medication called T-DXd but have either not responded or cannot tolerate it.Participants will be randomly assigned …
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This study investigates the efficacy and safety of an investigational medication in adults with relapsed or refractory indolent B-cell Non-Hodgkin Lymphoma (NHL), specifically follicular lymphoma (FL) and marginal zone lymphoma (MZL). The purpose of this study is to understand how well the investigational medication works in treating these types of …
The primary purpose of this research study is to obtain specimens (blood, bone marrow, and other tissues) for research about multiple myeloma and related diseases.
This study investigates the impact of a supervised exercise program on outcomes for older adults undergoing allogeneic hematopoietic cell transplantation (HCT). The purpose of this study is to see if such an exercise program can be successfully implemented.Participants will be divided into two study arms: Cohort A (Prehab) and Cohort …
This study investigates the use of an investigational drug called ziftomenib in combination with standard treatments for patients with acute myeloid leukemia (AML). This study focuses on patients with specific genetic changes, such as NPM1 mutations or KMT2A rearrangements, and includes those who are newly diagnosed as well as those …
This study investigates a potential treatment for Acute Myeloid Leukemia (AML). The purpose of this study is to explore the use of a modified stem cell transplant combined with engineered T cells, known as chimeric antigen receptor (CAR) T cells, to target and attack leukemia cells. CAR T cells are …
This study investigates a treatment for patients with acute myeloid leukemia (AML) who are not eligible for bone marrow transplantation. The purpose of the study is to evaluate the safety and tolerability of an investigational medication given as maintenance therapy. Patients in this study have AML, which is a type …
This study investigates the effectiveness of preoperative chemotherapy followed by surgery compared to surgery alone in patients with high-risk retroperitoneal sarcoma, specifically dedifferentiated liposarcoma (DDLPS) and leiomyosarcoma (LMS). The study aims to determine if adding chemotherapy before surgery can improve disease-free survival for these patients.Participants in the study will be …
This study investigates the use of investigational immunotherapy called Chimeric Antigen Receptor T Cells (CAR T Cells) for patients awaiting kidney transplantation. These patients have a high calculated Panel Reactive Antibody (cPRA) of 99.5% or higher, indicating a likelihood of rejecting most available kidneys. The study aims to determine if …
This study investigates the effectiveness, safety, and how the body processes an investigational medication in patients with Primary Central Nervous System Lymphoma (PCNSL). The study has two parts: Part A involves patients with PCNSL that has returned or not responded to previous treatments, and Part B involves patients who have …
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