Found 42 genetics trials
A listing of genetics medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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Requesting a reliance agreement with an external IRB. The objectives are to evaluate the long-term safety and tolerability of pelacarsen (TQJ230) in participants with elevated Lp(a) and established CVD who have completed the parent Lp(a)HORIZON study, evaluate the long-term efficacy of pelacarsen (TQJ230) on 4P-MACE, and to evaluate the long-term …
The study is a clinical trial open to people who require additional lowering of low-density lipoprotein cholesterol (LDL-C) and who also have a genetic condition called heterozygous familial hypercholesterolemia (HeFH) and/or evidence of premature coronary artery disease (CAD). Premature CAD is the narrowing or blockage of arteries that supply the …
This study investigates pulmonary hypertension associated with interstitial lung disease (PH-ILD) and interstitial lung disease (ILD).The study focuses on understanding patient characteristics, treatment patterns, and clinical outcomes for PH-ILD. It evaluates the disease progression in ILD patients who are at risk for pulmonary hypertension.Who can participate: Adults aged 18 years …
This study investigates the safety and initial effects of a gene therapy for patients with a type of inherited eye disease called LCA5-associated inherited retinal degeneration (LCA5-IRD). The purpose is to understand how this condition progresses over time and to see how patients respond to different doses of an investigational …
This study investigates retinal dystrophy. The purpose of this study is to gather information about genetic variants associated with this condition.The study evaluates the natural history and structural-functional relationships of genetic variants in retinal dystrophy. It also looks into risk factors for progression and investigates subpopulations for future clinical trials.Who …
This study investigates the presence of certain brain proteins in people with conditions like Progressive Supranuclear Palsy, Corticobasal Syndrome, genetic Frontotemporal Lobar Degeneration, Parkinson's Disease, Alzheimer's Disease, and healthy individuals. These conditions are collectively known as tauopathies.The study evaluates how a special substance, which can be seen in brain scans, …
This study investigates genetic and familial dilated cardiomyopathy (DCM).The study evaluates the safety and effectiveness of an investigational medication compared to a placebo.Who can participate: Adults diagnosed with genetic or familial DCM, with stable symptoms and certain heart function criteria, may participate. Participants should not have DCM due to other …
The purpose of this study is to characterize gene mutations associated Central Centrifugal Cicatricial Alopecia (CCCA). The Penn Medicine BioBank (PMBB) supports researchers by providing centralized access to a large number of annotated blood and tissue samples. Clinician identified patients with CCCA and appropriate controls will be recruited from the …
The objectives of the study are to recruit patients with tumors of the autonomic nervous system and develop an annotated database including tissue samples to facilitate research with the goal of better understanding the genetics and biochemical signaling pathways leading to tumor formation and malignancy. The primary goal of this …
Create a foundational resource for conducting and sharing ATN imaging and blood biomarker results in the context of the large clinically heterogenous brain-donor-enrolled multi-ADRC cohort. These imaging-plasma sets will be intrinsically linked to cognitive and neurobehavioral data collection, genetics and eventually neuropathology.
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