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Found 389 oncology trials
A listing of oncology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the use of autologous CAR T cells, specifically DSG3-CAART and CABA-201, in individuals with active pemphigus vulgaris (PV). This research aims to evaluate the safety and dosing of these investigational cell therapies in patients whose condition is not adequately controlled by standard treatments.Participants in this study will …
The purpose of this study is to investigate the effectiveness and safety of an investigational medication compared to standard endocrine therapy for patients with ER+/HER2- early breast cancer. The study focuses on patients who have completed locoregional treatment, which may include surgery and radiotherapy, and are at intermediate-high or high …
Study on Investigational Medication for Relapsed or Refractory Plasma Cell Cancer (Multiple Myeloma)
This study investigates the effects of an investigational medication on individuals with relapsed or refractory multiple myeloma. The purpose of the study is to evaluate the safety, tolerability, and effectiveness of the investigational medication when used alone or in combination with other cancer treatments.Participants in the study will receive the …
The purpose of this study is to learn how participant factors (such as medical history and manufacturing starting material, also known as Apheresis) can predict successful manufacturing of ciltacabtagene autoleucel (Cilta-cel). This information can be used to potentially improve manufacturing processes and treat more patients with Cilta-cel. We would like …
This study investigates the use of an investigational medication, epcoritamab, before and after CAR-T cell therapy in patients with relapsed or refractory large B-cell lymphomas. This study aims to understand if epcoritamab can improve outcomes when used in conjunction with CAR-T cell therapy, a treatment where a patient's T cells …
This study investigates the use of an investigational therapy for patients who have been diagnosed with a condition approved for treatment with this therapy, but whose therapy does not meet commercial release criteria. The purpose is to provide access to this investigational treatment under specific conditions.Participants in this study will …
This study investigates the effects of an investigational medication on patients with relapsed and refractory multiple myeloma (RRMM). The purpose of the study is to evaluate the safety and effects of a selective inhibitor that targets a specific enzyme involved in the disease process.Participants will undergo a dose-escalation phase to …
This study investigates the safety and effectiveness of combining two investigational medications, SNDX-5613 and gilteritinib, for treating relapsed or refractory acute myeloid leukemia (AML) with specific genetic mutations. This study focuses on patients whose leukemia has returned or not responded to treatment and who have mutations in the FLT3 gene, …
This study investigates the safety and tolerability of β-hydroxybutyrate (BHB) supplementation in patients receiving standard-of-care anti-CD19 CAR T-cells for the treatment of lymphoma. The purpose of this study is to determine if BHB supplementation, administered orally, affects the gut microbiome and peripheral blood mononuclear cells (PBMCs) in these patients.Participants will …
This study investigates the effects of adding an investigational medication to an existing treatment with ruxolitinib for patients with myelofibrosis. The purpose of this study is to determine if the investigational medication can provide more benefits than ruxolitinib alone for patients who have not responded well to ruxolitinib by itself.Participants …
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