Found 57 ne-neurology trials
A listing of ne-neurology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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The study is designed to evaluate the efficacy and safety of intraputaminal delivery of AAV2-GDNF gene therapy in subjects with moderate Parkinson's disease and demonstrate proof-of-concept. Subjects will be randomized to 1 of 2 treatment arms, AAV2-GDNF surgery or control surgery and will undergo screening, two baseline visits, perioperative procedures, …
Primary Objective: To compare the efficacy of 2 doses of BHV-7000 to placebo as an adjunctive therapy for refractory focal onset epilepsy as measured by the change from baseline in 28-day average seizure frequency. Secondary Objcetives: -To compare the efficacy of 2 doses of BHV-7000 to placebo as adjunctive therapy …
This study investigates the effects of an investigational medication in individuals with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. The purpose of this study is to understand how the investigational medication, combined with standard immunomodulatory therapies, affects patients with moderate-to-severe NMDAR encephalitis.Participants in this study will receive either the investigational medication or a …
This is a phase 3 trial of AOC 1001, an antibody-oligonucleotide conjugate. Protocol includes participants ages 16-65 with a clinical and genetic diagnosis of DM1 with DMPK CTG repeat length greater than or equal to 100; Penn site will enroll ages 18 to 65 years only. Participants will be randomized …
Study to assess the safety and tolerability of XEN1101 versus placebo on reducing primary generalized tonic clonic seizures in patients with these kinds of seizures. PGTCS frequency in subjects with PGTCS.
To collect and store blood samples and genetic data from all patients with PD who receive medical care at the University of Pennsylvania PDMDC to support research needs. To link biospecimens to clinical data in an encrypted database. To encourage collaboration within the University of Pennsylvania and through external collaboration. …
To characterize the neurophysiologic signatures of movement disorders symptoms in conditions such as Parkinson's disease, essential tremor, ataxia, and dystonia.
This study evaluates the safety, pharmacodynamics, and exploratory clinical efficacy of an investigational medication as an add-on treatment for LOPD.The focus is on assessing how safe and effective the investigational medication is when used in combination with existing treatments.Who can participate: Adults aged 18 or older, weighing at least 40 …
This study investigates dystonia. It is an observational study that collects detailed information about how dystonia affects patients' lives and how the disease changes over time. The study also looks at how clinical scales are used to evaluate symptoms and their impact on well-being, pain, relationships, and social interactions.The purpose …
To collect and store blood samples and genetic data from all patients with PD who receive medical care at the University of Pennsylvania PDMDC to support research needs. To link biospecimens to clinical data in an encrypted database. To encourage collaboration within the University of Pennsylvania and through external collaboration. …
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