Found 19 Lancaster General Health trials
A listing of Lancaster General Health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Phase 4
The purpose of this registry is to understand the safety and effectiveness of various medications used in treating the condition of symptomatic obstructive hypertrophic cardiomyopathy (HCM), a type of heart disease that causes the muscular wall in the chambers of the heart to thicken which can cause blood flow in …
Phase 4
The purpose of this study is to evaluate the effect of breath training on patients with systolic heart failure. The study evaluates patients and incorporates the use of smart phone technology for breath training at baseline and at three and six months, using the 6-minute walk test, a standard heart …
The purpose of this study is to evaluate if closing off the left atrial appendage (LAA) of your heart (a small-sack like structure that is part of the upper chamber of the heart) during scheduled heart surgery with a surgical device known as the AtriClip, reduces the risk of a …
Phase 3
This trial is testing MK-7684A when given in combination with chemotherapy plus radiation therapy (concurrent chemoradiotherapy or cCRT). This trial is for people with stage 3 non-small cell lung cancer (NSCLC). Receiving cCRT is part of the standard treatment for patients with stage 3 NSCLC. MK-7684A, an experimental treatment, is …
Phase 2
The objectives of this study are to evaluate the efficacy of luveltamab tazevibulin in subjects with relapsed platinum-resistant epithelial ovarian cancer expressing FOLR1. In addition to this main objective, the study will also assess the additional efficacy outcome measures, as well as the safety and tolerability of luveltamab tazevibulin in …
The OPTIMIZER Smart Post-Approval Study (PAS) is a single arm open label study of 620 participants receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%.
This research study seeks to validate how echocardiogram (echo) data predicts response to cardiac resynchronization therapy (CRT) provided by a CRT device with a defibrillator (CRT-D) in individuals without the heart arrhythmia abnormality left bundle branch block (LBBB). It also aims to identify new variables recorded from electrocardiograms (ECG) or …
Phase 3
This study will determine if ziltivekimab, a monoclonal antibody, can be used to treat people living with heart failure and inflammation. Previous studies showed that ziltivekimab can lower inflammation, which may have a positive effect on heart failure symptoms. The HERMES study will look more into this effect. Also, the …
This post-approval study (PAS) evaluates real world usage of the ENROUTE Transcarotid Stent when used with the ENROUTE Transcarotid Neuroprotection System in patients at standard risk for adverse events from carotid endarterectomy (a procedure to treat carotid artery disease). The study will enroll up to 400 patients at 30-60 sites …
Phase 4
This study will compare treating participants with standard care, combined with early treatment with a cholesterol lowering drug called evolocumab (Repatha®) to treating participants with standard care alone. The study will measure reductions in heart attacks and strokes, procedures to improve blood flow, and death, compared to regular healthcare alone.
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