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Found 938 All Conditions trials
A listing of All Conditions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the safety and performance of an investigational heart valve system in patients with clinically significant, symptomatic mitral regurgitation. Participants in this study will undergo procedures to implant the investigational heart valve system. The study will closely monitor participants for any side effects or complications related to the …
Systemic sclerosis is a rare chronic autoimmune connective tissue disease. B cells have been reported to play a central role in the pathogenesis of SSc and B cell depletion has been shown to offer benefit to patients with SSc. Belimumab is a monoclonal antibody, which inhibits the survival of B …
This study investigates the effects of an investigational medication on nonobstructive hypertrophic cardiomyopathy (noHCM).The study evaluates the safety and potential benefits of the investigational medication in improving exercise capacity and cardiac function.Who can participate: Adults with a diagnosis of hypertrophic cardiomyopathy who can take oral medication and comply with study …
Primary Objectives Determine biodistribution of the radioactive investigational drug, 11C M503 and calculate human dosimetry (at least 10 male and female participants). Demonstrate the feasibility of imaging the brain with the novel imaging agent 11C M503 Determine the most appropriate data analysis methodology. Determine whether there is selective uptake of …
The study is designed to evaluate the efficacy and safety of intraputaminal delivery of AAV2-GDNF gene therapy in subjects with moderate Parkinson's disease and demonstrate proof-of-concept. Subjects will be randomized to 1 of 2 treatment arms, AAV2-GDNF surgery or control surgery and will undergo screening, two baseline visits, perioperative procedures, …
This study investigates the safety and effectiveness of an investigational atrioventricular interval modulation (AVIM) algorithm in patients with dual-chamber pacemakers.The study evaluates how well the investigational AVIM algorithm works when downloaded into a specific type of pacemaker. It looks at whether this algorithm can be safely used and how effective …
This study investigates fibrotic conditions. It uses Fibroblast Activating Protein (FAP) PET/CT imaging to look at fibrosis caused by different medical conditions.The study evaluates if this imaging method can show how fibrosis affects major organs and tissues. It focuses on understanding the distribution of FAP in the body.Who can participate: …
This study investigates heart failure due to left ventricular systolic dysfunction. It focuses on comparing two types of pacing: His bundle branch pacing and Left bundle branch pacing.The study evaluates the effectiveness and safety of these pacing methods. It looks at how they impact quality of life, physical activity, and …
The protocol is for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred …
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