R33_MDD | Clinical Research Studies Listing

Recruiting

99 years or below

All

Phase N/A

150 participants needed

1 Location

Brief description of study

The purpose of this study is to investigate whether brain responses within the subgenual anterior cingulate cortex (sgACC) are associated with clinical improvement following transcranial magnetic stimulation (TMS) treatment in individuals with depression. Participants will be randomized to receive either active or sham intermittent theta-burst stimulation (iTBS) delivered to an individualized, fMRI-guided cortical target over a 6-week treatment course. The study will examine whether sgACC responses measured using interleaved TMS and functional magnetic resonance imaging (TMS/fMRI) before treatment predict antidepressant response and whether changes in sgACC responses throughout treatment are associated with changes in depressive symptoms. Study participation will include clinical interviews, questionnaires, MRI scans, interleaved TMS/fMRI sessions conducted before, during, and after treatment, and weekday TMS sessions for approximately 6 weeks.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research
Age: 99 years or below
Gender: All

TBD

Updated on 17 Sep 2026. Study ID: 26-7480

Find a site

Your Information has been sent successfully.

We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.

Would you like to be notified about other trials? Sign up for Patient Notification Services.

Send a message

Enter your contact details to connect with study team

View email

Phone

View phone

First name*

Last name*

Email*

Phone number*

Preferred way of contact

Please provide your preferred way of contact

Other language

By Submitting your information, you agree that your details may be shared with the selected study site and handled in accordance with this Website's Privacy Policy (see link in footer). You may be contacted by email, text message, or phone regarding this study and other research opportunities that may be of interested to you. You can unsubscribe from these communications at any time. Message and data rates may apply.

Interested in the study

Select a study center that’s convenient for you, and get in touch with the study team.

Contact a study center