UPCC 02025 A Prospective Study of Low Dose Radiotherapy for Osteoarthritis

Study of Low Dose Radiotherapy for Osteoarthritis

Enrolling By Invitation
18 years or above
All
Phase N/A
113 participants needed
1 Location

Brief description of study

This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.

Detailed description of study

To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Osteoarthitis
  • Age: 18 years or above
  • Gender: All

Inclusion Criteria:

  • 18 years or older
  • Diagnosis of OA >3 months in hips, knees, hands, shoulders, ankles or elbows.
  • Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
  • Provision of signed and dated informed consent.

Exclusion Criteria:

  • Unable to reasonably complete study instruments.

This study investigates osteoarthritis. It focuses on understanding changes in pain and function when treated with low dose radiotherapy (LDRT).

The study evaluates how well certain tools measure changes in pain, function, and well-being in people with osteoarthritis who have not responded to other treatments.

  • Who can participate: Adults aged 18 and older with osteoarthritis in specific joints for more than 3 months can participate. Participants should have tried standard treatments without success or be considering more aggressive treatments.
  • Study details: Participants will report on changes in their pain and function.
Updated on 20 Jul 2026. Study ID: 25-2194
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