UPCC 02026 A Cluster Randomized Controlled Trial Testing Communication Strategies to Increase HPV Vaccination in Primary Care

Investigating Communication Strategies for Increasing HPV Vaccination in Adults

Enrolling By Invitation
18 years - 45 years
All
Phase N/A
5337 participants needed
1 Location

Brief description of study

This research aims to identify communication strategies to improve the uptake of vaccines using an experimental design, focusing on the Human Papillomavirus (HPV) vaccine, which is highly effective in preventing HPV-related cancers. However, low HPV vaccination rates among adults remain a significant public health challenge. Although randomized controlled trials (RCTs) have demonstrated that interventions can increase vaccine uptake in children, few RCTs have been conducted on adults. To address this gap, a multidisciplinary investigative team with expertise in communication, medicine, nursing, and behavior-change intervention research, and a history of extensive collaboration, will conduct a survey experiment on a national sample of over 3,689 adults to identify the most promising theory-based messages to strengthen HPV vaccine intentions.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Papilloma Viral Infection, Vaccine Hesitancy, Communication
  • Age: 18 years - 45 years
  • Gender: All

Inclusion Criteria:

  • 18-45 years old

Exclusion Criteria:

  • Under 18 and over 45 years old
  • Received HPV vaccine or unsure about receipt

The purpose of this study is to investigate communication strategies to increase the uptake of the HPV vaccine among adults. The study focuses on finding effective ways to communicate the importance of the HPV vaccine to adults, as the vaccination rates are currently low in this group.

Participants in this study will take part in a survey experiment. The survey will present different messages about the HPV vaccine, based on theories of behavior change, to see which messages are most effective in increasing vaccine intentions. The study involves a national sample of over 3,689 adults.

  • Who can participate: Adults aged 18 to 45 years who have not received the HPV vaccine or are unsure about their vaccination status are eligible to participate.
  • Study details: Participants will be involved in a survey experiment where they will be exposed to different messages about the HPV vaccine to assess their impact on vaccine intentions.
Updated on 04 Jun 2026. Study ID: 24-1618
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