Precision Depression Adalimumab Trial | Clinical Research Studies Listing

Recruiting

18 years or above

All

Phase N/A

60 participants needed

1 Location

Brief description of study

The Precision Psychopathology +Dynamic Immunopsychiatry (PPDI) Lab is looking for people who are currently experiencing depression to participate in a clinical trial designed to measure the effect of an anti-inflammatory medication (Simlandi/adalimumab-ryvk) on persisting depression symptoms in people already taking an anti-depressant.

Detailed description of study

If eligible, participants will receive FREE injections of Simlandi or placebo every 2 weeks for 2 months at Penn’s Outpatient Psychiatry Clinic. The study treatment and all tests and visits required are provided at no cost to you. You will receive up to $175 in compensation for your participation, in addition to reimbursement for parking.

The study team will discuss additional study requirements with you if necessary. In addition to biweekly injections of Simlandi or placebo, participants will complete an online survey (<5 minutes) every day.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research
Age: 18 years or above
Gender: All

You may be able to participate in this study if you:

Are 18 years or older
Are diagnosed with Major depressive Disorder (MDD) and are currently experiencing symptoms
Have been taking a stable dose of Lexapro for at least 2 weeks
Have no immune-related disorders
Are willing to receive physician-administered injections

Updated on 28 Aug 2026. Study ID: 25-1129

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