VX24-KDO-901

Study on PKD1/2 Gene Variants in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients

Recruiting
12 years - 65 years
All
Phase N/A
401 participants needed
1 Location

Brief description of study

The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Autosomal Dominant Polycystic Kidney Disease (ADPKD)
  • Age: 12 years - 65 years
  • Gender: All

Key Inclusion Criteria:

  • Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 30 milliliter per minute (mL/min)/1.73 m^2
  • Willing and able to comply with scheduled visits and other study procedures
  • A pre-existing diagnosis of ADPKD as defined in the protocol

Key Exclusion Criteria:

  • History of kidney disease other than ADPKD that in the opinion of the investigator would independently impact the natural history of ADPKD
  • History of solid organ or bone marrow transplantation or nephrectomy
  • Ongoing renal replacement therapy or planning to start renal replacement therapy less than or equal to (≤)12 months from the Genotyping Visit in Part A

Other protocol defined Inclusion/Exclusion criteria will apply.

The purpose of this study is to investigate ADPKD, focusing on the PKD1/2 gene variants. The study looks at how common these gene variants are and the characteristics of people who have them.

This study evaluates the different traits and demographics of individuals with these gene variants. It explores the clinical aspects linked to these variants in the ADPKD population.

  • Who can participate: Adults with an estimated glomerular filtration rate (eGFR) of at least 30 mL/min/1.73 m^2 and a pre-existing diagnosis of ADPKD can participate if they are willing to comply with study procedures.
  • Study details: Participants will provide information and samples for genetic testing to identify PKD1/2 gene variants and attend scheduled visits as part of the study.
Updated on 21 Jul 2026. Study ID: 25-1080

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