Single-Pulse TMS and Intracranial Electrode Recordings

Recruiting

21 years - 75 years

All

Phase N/A

10 participants needed

1 Location

Brief description of study

To test if TMS to MRI-guided cortical targets can create neuronal activity changes in downstream regions of interest
To determine if TMS-sEEG is a valid research approach to study circuit engagement and specific connections of deep brain nuclei in the human brain
To investigate the effects of clinically relevant TMS paradigms on electrophysiology in downstream regions of interest, circuit engagement, and connectivity 1. Observation of effects in brain activity and connectivity within and across regions of interest before and after TMS, as measured by intracranial EEG
Safety, as defined by the number of adverse events (AE) N/A

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research
Age: 21 years - 75 years
Gender: All

Inclusion Criteria:

Patients who received (or are scheduled to receive) intracranial electrode implantation surgery as part of standard clinical care or as participation in an ongoing research study for the treatment of neurological and/or psychiatric conditions at Pennsylvania Hospital
Adult patients, 21 to 75 years of age
Patients considered to be in a stable medical condition, in the opinion of the PI
Patients who are able to demonstrate comprehension of instructions in the English language, in the opinion of the PI
Patients who are able to provide informed consent and fully comply with all study requirements, in the opinion of the PI

Exclusion Criteria:

Patients with chronic alcohol abuse history
Patients who are unable to have an MRI scan
Patients who are unable to tolerate TMS
Patients with additional implanted devices, such as an aneurysm clip or a cardiac pacemaker, that would increase the TMS risk profile
Patients who are pregnant at the time of screening or patients who get pregnant during the course of the study
Patients with any past or present medical condition, disease, disorder, or injury that, in the opinion of the PI, may reduce or hinder the participant’s ability to fully comply with all study requirements or may impact, compromise, or affect the integrity of the data or the results of the study

Updated on 02 Apr 2026. Study ID: 24-2321

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